The Ley Lab Researching AML at Washington University in St Louis

All Publications

2023

Proteogenomic analysis reveals cytoplasmic sequestration of RUNX1 by the acute myeloid leukemia-initiating CBFB::MYH11 oncofusion protein.
Proteogenomic analysis reveals cytoplasmic sequestration of RUNX1 by the acute myeloid leukemia-initiating CBFB::MYH11 oncofusion protein.
Ryan B Day, Julia A Hickman, Ziheng Xu, Casey Ds Katerndahl, Francesca Ferraro, ..., Robert W Sprung, Yiling Mi, R Reid Townsend, Christopher A Miller, Timothy J Ley
The Journal of clinical investigation   ·   07 Dec 2023   ·   pubmed:38061017
Genomic landscape of TP53-mutated myeloid malignancies.
Genomic landscape of TP53-mutated myeloid malignancies.
Haley J Abel, Karolyn A Oetjen, Christopher A Miller, Sai M Ramakrishnan, Ryan B Day, ..., Matthew J Walter, Peter Westervelt, John F DiPersio, Timothy J Ley, Daniel C Link
Blood advances   ·   22 Aug 2023   ·   pubmed:37339484
Melanoma in a patient with DNMT3A overgrowth syndrome.
Melanoma in a patient with DNMT3A overgrowth syndrome.
David Y Chen, Leslie A Sutton, Sai Mukund Ramakrishnan, Eric J Duncavage, Sharon E Heath, Leigh A Compton, Christopher A Miller, Timothy J Ley
Cold Spring Harbor molecular case studies   ·   09 May 2023   ·   pubmed:37160317
Persistent Molecular Disease in Adult Patients With AML Evaluated With Whole-Exome and Targeted Error-Corrected DNA Sequencing.
Persistent Molecular Disease in Adult Patients With AML Evaluated With Whole-Exome and Targeted Error-Corrected DNA Sequencing.
Michael J Slade, Reza Ghasemi, Michelle O'Laughlin, Tasha Burton, Robert S Fulton, Haley J Abel, Eric J Duncavage, Timothy J Ley, Meagan A Jacoby, David H Spencer
JCO precision oncology   ·   01 Apr 2023   ·   pubmed:37079859
Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions.
Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions.
Georgina L Ryland, Masayuki Umeda, Linda Holmfeldt, Sören Lehmann, Morten Krogh Herlin, ..., Timothy J Ley, Soheil Meshinchi, Xiaotu Ma, Piers Blombery, Jeffery M Klco
Blood   ·   16 Feb 2023   ·   pubmed:36179268
Genomic landscape of
Genomic landscape of
Haley J Abel, Karolyn A Oetjen, Christopher A Miller, Sai M Ramakrishnan, Ryan B Day, ..., Matthew J Walter, Peter Westervelt, John F DiPersio, Timothy J Ley, Daniel C Link
medRxiv : the preprint server for health sciences   ·   11 Jan 2023   ·   pubmed:36711871

2022

IL-1β expression in bone marrow dendritic cells is induced by TLR2 agonists and regulates HSC function.
IL-1β expression in bone marrow dendritic cells is induced by TLR2 agonists and regulates HSC function.
Sidan Li, Juo-Chin Yao, Karolyn A Oetjen, Joseph R Krambs, Jun Xia, ..., Isaiah R Turnbull, Gabriel Mbalaviele, Timothy J Ley, Matthew J Walter, Daniel C Link
Blood   ·   06 Oct 2022   ·   pubmed:35675516
Proteomic and phosphoproteomic landscapes of acute myeloid leukemia.
Proteomic and phosphoproteomic landscapes of acute myeloid leukemia.
Michael H Kramer, Qiang Zhang, Robert Sprung, Ryan B Day, Petra Erdmann-Gilmore, ..., Daniel C Link, John F DiPersio, Matthew J Walter, R Reid Townsend, Timothy J Ley
Blood   ·   29 Sep 2022   ·   pubmed:35895896
Author Correction: A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing.
Author Correction: A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing.
Allegra A Petti, Stephen R Williams, Christopher A Miller, Ian T Fiddes, Sridhar N Srivatsan, David Y Chen, Catrina C Fronick, Robert S Fulton, Deanna M Church, Timothy J Ley
Nature communications   ·   21 Jul 2022   ·   pubmed:35864110
Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression.
Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression.
Andrew J Menssen, Ajay Khanna, Christopher A Miller, Sridhar Nonavinkere Srivatsan, Gue Su Chang, ..., Matthew J Schuelke, Meagan A Jacoby, Eric J Duncavage, Timothy J Ley, Matthew J Walter
Blood cancer discovery   ·   06 Jul 2022   ·   pubmed:35709710
Decitabine salvage for
Decitabine salvage for
Francesca Ferraro, Agata Gruszczynska, Marianna B Ruzinova, Christopher A Miller, Mary Elizabeth Percival, ..., Lukas D Wartman, Feng Gao, Daniel C Link, Timothy J Ley, John S Welch
Haematologica   ·   01 Jul 2022   ·   pubmed:35236053
Physician-scientists in the United States at 2020: Trends and concerns.
Physician-scientists in the United States at 2020: Trends and concerns.
Howard H Garrison, Timothy J Ley
FASEB journal : official publication of the Federation of American Societies for Experimental Biology   ·   01 May 2022   ·   pubmed:35349197
Recurrent transcriptional responses in AML and MDS patients treated with decitabine.
Recurrent transcriptional responses in AML and MDS patients treated with decitabine.
Pawan Upadhyay, Jeremy Beales, Nakul M Shah, Agata Gruszczynska, Christopher A Miller, Allegra A Petti, Sai Mukund Ramakrishnan, Daniel C Link, Timothy J Ley, John S Welch
Experimental hematology   ·   13 Apr 2022   ·   pubmed:35429619
Somatic
Somatic
Amanda M Smith, Angela M Verdoni, Haley J Abel, David Y Chen, Shamika Ketkar, Elizabeth R Leight, Christopher A Miller, Timothy J Ley
iScience   ·   03 Mar 2022   ·   pubmed:35313694
Bam-readcount - rapid generation of basepair-resolution sequence metrics
Bam-readcount - rapid generation of basepair-resolution sequence metrics
Ajay Khanna, David Larson, Sridhar Srivatsan, Matthew Mosior, Travis Abbott, ..., Matthew Walter, Jason Walker, Obi Griffith, Malachi Griffith, Christopher Miller
Journal of Open Source Software   ·   29 Jan 2022   ·   10.21105/joss.03722
DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults.
DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults.
Margaret A Ferris, Amanda M Smith, Sharon E Heath, Eric J Duncavage, Matthew Oberley, ..., Saskia Koene, David H Spencer, Christopher A Miller, Marwan Shinawi, Timothy J Ley
Blood   ·   20 Jan 2022   ·   pubmed:34788385
Failure to Detect Mutations in U2AF1 due to Changes in the GRCh38 Reference Sequence.
Failure to Detect Mutations in U2AF1 due to Changes in the GRCh38 Reference Sequence.
Christopher A Miller, Jason R Walker, Travis L Jensen, William F Hooper, Robert S Fulton, ..., Mikkael A Sekeres, Timothy J Ley, David H Spencer, Johannes B Goll, Matthew J Walter
The Journal of molecular diagnostics : JMD   ·   15 Jan 2022   ·   pubmed:35041928
Tumor suppressor function of
Tumor suppressor function of
Matthew J Christopher, Casey D S Katerndahl, Hayley R LeBlanc, Tyler T Elmendorf, Vaishali Basu, ..., Shamika Ketkar, Lukas D Wartman, Sai Mukund Ramakrishnan, Christopher A Miller, Timothy J Ley
Haematologica   ·   01 Jan 2022   ·   pubmed:34670359

2021

Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes.
Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes.
Francesca Ferraro, Christopher A Miller, Keegan A Christensen, Nichole M Helton, Margaret O'Laughlin, ..., Daniel C Link, Matthew J Walter, Peter Westervelt, John F DiPersio, Timothy J Ley
Proceedings of the National Academy of Sciences of the United States of America   ·   07 Dec 2021   ·   pubmed:34845035
Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells.
Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells.
Elisabeth R Wilson, Nichole M Helton, Sharon E Heath, Robert S Fulton, Jacqueline E Payton, ..., John F DiPersio, Daniel C Link, Christopher A Miller, Timothy J Ley, David H Spencer
Leukemia   ·   06 Dec 2021   ·   pubmed:34873300
Tumor suppressor function of Gata2 in acute promyelocytic leukemia.
Tumor suppressor function of Gata2 in acute promyelocytic leukemia.
Casey D S Katerndahl, Olivia R S Rogers, Ryan B Day, Michelle A Cai, Timothy P Rooney, ..., Sai Mukund Ramakrishnan, Sridhar Nonavinkere Srivatsan, Lukas D Wartman, Christopher A Miller, Timothy J Ley
Blood   ·   30 Sep 2021   ·   pubmed:34125173
Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia.
Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia.
Allegra A Petti, Saad M Khan, Ziheng Xu, Nichole Helton, Catrina C Fronick, ..., Matthew J Walter, Daniel C Link, John DiPersio, Christopher Miller, Timothy J Ley
Blood cancer discovery   ·   24 Aug 2021   ·   pubmed:35019859
Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome.
Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome.
Amanda M Smith, Taylor A LaValle, Marwan Shinawi, Sai M Ramakrishnan, Haley J Abel, ..., Diana L Christian, Jenna R Martin, Harrison W Gabel, Christopher A Miller, Timothy J Ley
Nature communications   ·   27 Jul 2021   ·   pubmed:34315901
Bam-readcount - rapid generation of basepair-resolution sequence metrics.
Bam-readcount - rapid generation of basepair-resolution sequence metrics.
Ajay Khanna, David E Larson, Sridhar Nonavinkere Srivatsan, Matthew Mosior, Travis E Abbott, ..., Matthew J Walter, Jason R Walker, Obi L Griffith, Malachi Griffith, Christopher A Miller
ArXiv   ·   27 Jul 2021   ·   pubmed:34341766
Co-evolution of tumor and immune cells during progression of multiple myeloma.
Co-evolution of tumor and immune cells during progression of multiple myeloma.
Ruiyang Liu, Qingsong Gao, Steven M Foltz, Jared S Fowles, Lijun Yao, ..., Mark A Fiala, Stephen T Oh, John F DiPersio, Ravi Vij, Li Ding
Nature communications   ·   07 May 2021   ·   pubmed:33963182
Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.
Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.
David Y Chen, Ian M Ferguson, Krista A Braun, Leslie A Sutton, Nichole M Helton, Sai Mukund Ramakrishnan, Amanda M Smith, Christopher A Miller, Timothy J Ley
Proceedings of the National Academy of Sciences of the United States of America   ·   20 Apr 2021   ·   pubmed:33846253
Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers.
Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers.
Eric J Duncavage, Molly C Schroeder, Michele O'Laughlin, Roxanne Wilson, Sandra MacMillan, ..., Matthew J Walter, Peter Westervelt, John F DiPersio, Timothy J Ley, David H Spencer
The New England journal of medicine   ·   11 Mar 2021   ·   pubmed:33704937
Impact of a 40-Gene Targeted Panel Test on Physician Decision Making for Patients With Acute Myeloid Leukemia.
Impact of a 40-Gene Targeted Panel Test on Physician Decision Making for Patients With Acute Myeloid Leukemia.
Erica K Barnell, Kenneth F Newcomer, Zachary L Skidmore, Kilannin Krysiak, Sydney R Anderson, ..., Eric J Duncavage, Timothy J Ley, Malachi Griffith, Meagan A Jacoby, Obi L Griffith
JCO precision oncology   ·   14 Jan 2021   ·   pubmed:34036230
Enhanced Efficacy and Increased Long-Term Toxicity of CNS-Directed, AAV-Based Combination Therapy for Krabbe Disease.
Enhanced Efficacy and Increased Long-Term Toxicity of CNS-Directed, AAV-Based Combination Therapy for Krabbe Disease.
Yedda Li, Christopher A Miller, Lauren K Shea, Xuntian Jiang, Miguel A Guzman, ..., Charles P Venditti, Carole A Vogler, Daniel S Ory, Timothy J Ley, Mark S Sands
Molecular therapy : the journal of the American Society of Gene Therapy   ·   01 Jan 2021   ·   pubmed:33388420

2020

The clonal evolution of metastatic colorectal cancer.
The clonal evolution of metastatic colorectal cancer.
Ha X Dang, Bradley A Krasnick, Brian S White, Julie G Grossman, Matthew S Strand, ..., Elaine R Mardis, Richard K Wilson, Timothy J Ley, Christopher A Maher, Ryan C Fields
Science advances   ·   10 Jun 2020   ·   pubmed:32577507
Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression.
Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression.
Jessica M Silva-Fisher, Ha X Dang, Nicole M White, Matthew S Strand, Bradley A Krasnick, ..., Richard K Wilson, Timothy J Ley, Albert C Lockhart, Ryan C Fields, Christopher A Maher
Nature communications   ·   01 May 2020   ·   pubmed:32358485
Remethylation of
Remethylation of
Shamika Ketkar, Angela M Verdoni, Amanda M Smith, Celia V Bangert, Elizabeth R Leight, ..., Gue Su Chang, Allegra A Petti, David H Spencer, Christopher A Miller, Timothy J Ley
Proceedings of the National Academy of Sciences of the United States of America   ·   29 Jan 2020   ·   pubmed:31996479

2019

Obesity is a risk factor for acute promyelocytic leukemia: evidence from population and cross-sectional studies and correlation with FLT3 mutations and polyunsaturated fatty acid metabolism.
Obesity is a risk factor for acute promyelocytic leukemia: evidence from population and cross-sectional studies and correlation with FLT3 mutations and polyunsaturated fatty acid metabolism.
Luca Mazzarella, Edoardo Botteri, Anthony Matthews, Elena Gatti, Davide Di Salvatore, ..., Timothy J Ley, Miguel Sanz, Krishnan Bhaskaran, Francesco Lo Coco, Pier Giuseppe Pelicci
Haematologica   ·   12 Sep 2019   ·   pubmed:31515354
A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing.
A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing.
Allegra A Petti, Stephen R Williams, Christopher A Miller, Ian T Fiddes, Sridhar N Srivatsan, David Y Chen, Catrina C Fronick, Robert S Fulton, Deanna M Church, Timothy J Ley
Nature communications   ·   14 Aug 2019   ·   pubmed:31413257
Immune Escape of AML Cells after Transplantation. Reply.
Immune Escape of AML Cells after Transplantation. Reply.
Matthew Christopher, John F DiPersio, Timothy J Ley
The New England journal of medicine   ·   28 Mar 2019   ·   pubmed:30917273

2018

Immune Escape of Relapsed AML Cells after Allogeneic Transplantation.
Immune Escape of Relapsed AML Cells after Allogeneic Transplantation.
Matthew J Christopher, Allegra A Petti, Michael P Rettig, Christopher A Miller, Ezhilarasi Chendamarai, ..., Daniel C Link, Matthew J Walter, Peter Westervelt, Timothy J Ley, John F DiPersio
The New England journal of medicine   ·   31 Oct 2018   ·   pubmed:30380364
Mutation Clearance after Transplantation for Myelodysplastic Syndrome.
Mutation Clearance after Transplantation for Myelodysplastic Syndrome.
Eric J Duncavage, Meagan A Jacoby, Gue Su Chang, Christopher A Miller, Natasha Edwin, ..., Peter Westervelt, Timothy J Ley, Kathryn Trinkaus, Timothy A Graubert, Matthew J Walter
The New England journal of medicine   ·   13 Sep 2018   ·   pubmed:30207916
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Maria C Trissal, Terrence N Wong, Juo-Chin Yao, Rahul Ramaswamy, Iris Kuo, ..., Todd A Fehniger, Timothy J Ley, Ivan Maillard, Pavan R Reddy, Daniel C Link
Cancer research   ·   03 May 2018   ·   pubmed:29724719
Sequencing of Tumor DNA to Guide Cancer Risk Assessment and Therapy.
Sequencing of Tumor DNA to Guide Cancer Risk Assessment and Therapy.
David H Spencer, Timothy J Ley
JAMA   ·   10 Apr 2018   ·   pubmed:29634818
DNMT3A
DNMT3A
David Chen, Matthew Christopher, Nichole M Helton, Ian Ferguson, Timothy J Ley, David H Spencer
Blood cancer journal   ·   04 Apr 2018   ·   pubmed:29618788
Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant.
Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant.
Meagan A Jacoby, Eric J Duncavage, Gue Su Chang, Christopher A Miller, Jin Shao, ..., John F DiPersio, Peter Westervelt, Timothy J Ley, Timothy A Graubert, Matthew J Walter
JCI insight   ·   08 Mar 2018   ·   pubmed:29515031
Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential.
Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential.
Terrence N Wong, Christopher A Miller, Matthew R M Jotte, Nusayba Bagegni, Jack D Baty, ..., John S Welch, Timothy A Graubert, Matthew J Walter, Timothy J Ley, Daniel C Link
Nature communications   ·   31 Jan 2018   ·   pubmed:29386642
Expression profiling of snoRNAs in normal hematopoiesis and AML.
Expression profiling of snoRNAs in normal hematopoiesis and AML.
Wayne A Warner, David H Spencer, Maria Trissal, Brian S White, Nichole Helton, Timothy J Ley, Daniel C Link
Blood advances   ·   23 Jan 2018   ·   pubmed:29365324

2017

Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies.
Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies.
Christopher B Cole, David A Russler-Germain, Shamika Ketkar, Angela M Verdoni, Amanda M Smith, ..., Robert Fulton, Gue Su Chang, Allegra A Petti, Christopher A Miller, Timothy J Ley
The Journal of clinical investigation   ·   05 Sep 2017   ·   pubmed:28872462
Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes.
Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes.
Jin Zhang, Malachi Griffith, Christopher A Miller, Obi L Griffith, David H Spencer, ..., Jeffery M Klco, Elaine R Mardis, Timothy J Ley, Richard K Wilson, Christopher A Maher
Experimental hematology   ·   28 Jul 2017   ·   pubmed:28760689
Decitabine in TP53-Mutated AML.
Decitabine in TP53-Mutated AML.
John S Welch, Allegra A Petti, Timothy J Ley
The New England journal of medicine   ·   23 Feb 2017   ·   pubmed:28225682
CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
David H Spencer, David A Russler-Germain, Shamika Ketkar, Nichole M Helton, Tamara L Lamprecht, ..., Richard K Wilson, Matthew J Walter, Daniel C Link, John F DiPersio, Timothy J Ley
Cell   ·   16 Feb 2017   ·   pubmed:28215704
Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy.
Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy.
Eric J Duncavage, Geoffrey L Uy, Allegra A Petti, Christopher A Miller, Yi-Shan Lee, ..., Peter Westervelt, Daniel C Link, John F DiPersio, Timothy J Ley, John S Welch
Blood   ·   12 Jan 2017   ·   pubmed:28082444

2016

TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.
TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.
John S Welch, Allegra A Petti, Christopher A Miller, Catrina C Fronick, Michelle O'Laughlin, ..., Matthew J Walter, Peter Westervelt, Daniel C Link, John F DiPersio, Timothy J Ley
The New England journal of medicine   ·   24 Nov 2016   ·   pubmed:27959731
Visualizing tumor evolution with the fishplot package for R.
Visualizing tumor evolution with the fishplot package for R.
Christopher A Miller, Joshua McMichael, Ha X Dang, Christopher A Maher, Li Ding, Timothy J Ley, Elaine R Mardis, Richard K Wilson
BMC genomics   ·   07 Nov 2016   ·   pubmed:27821060
Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy.
Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy.
G L Uy, E J Duncavage, G S Chang, M A Jacoby, C A Miller, ..., J S Welch, T J Ley, T A Graubert, P Westervelt, M J Walter
Leukemia   ·   14 Oct 2016   ·   pubmed:27740633
Targeted sequencing informs the evaluation of normal karyotype cytopenic patients for low-grade myelodysplastic syndrome.
Targeted sequencing informs the evaluation of normal karyotype cytopenic patients for low-grade myelodysplastic syndrome.
E J Duncavage, J O'Brien, K Vij, C A Miller, G S Chang, ..., M O'Laughlin, P Westervelt, T J Ley, R K Wilson, M J Walter
Leukemia   ·   30 Aug 2016   ·   pubmed:27573557
Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.
Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.
Malachi Griffith, Obi L Griffith, Kilannin Krysiak, Zachary L Skidmore, Matthew J Christopher, ..., Shashikant Kulkarni, John F DiPersio, Elaine R Mardis, Richard K Wilson, Timothy J Ley
Experimental hematology   ·   13 May 2016   ·   pubmed:27181063

2015

Patterns and functional implications of rare germline variants across 12 cancer types.
Patterns and functional implications of rare germline variants across 12 cancer types.
Charles Lu, Mingchao Xie, Michael C Wendl, Jiayin Wang, Michael D McLellan, ..., Benjamin J Raphael, Feng Chen, Kimberly J Johnson, Jeffrey D Parvin, Li Ding
Nature communications   ·   22 Dec 2015   ·   pubmed:26689913
Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.
Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.
Terrence N Wong, Christopher A Miller, Jeffery M Klco, Allegra Petti, Ryan Demeter, ..., John S Welch, Timothy A Graubert, Richard K Wilson, Timothy J Ley, Daniel C Link
Blood   ·   02 Dec 2015   ·   pubmed:26631115
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
Christopher B Cole, Angela M Verdoni, Shamika Ketkar, Elizabeth R Leight, David A Russler-Germain, Tamara L Lamprecht, Ryan T Demeter, Vincent Magrini, Timothy J Ley
The Journal of clinical investigation   ·   23 Nov 2015   ·   pubmed:26595813
Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.
Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.
Jane E Churpek, Khateriaa Pyrtel, Krishna-Latha Kanchi, Jin Shao, Daniel Koboldt, ..., John Welch, Richard Wilson, Timothy J Ley, Lucy A Godley, Timothy A Graubert
Blood   ·   22 Oct 2015   ·   pubmed:26492932
Optimizing cancer genome sequencing and analysis.
Optimizing cancer genome sequencing and analysis.
Malachi Griffith, Christopher A Miller, Obi L Griffith, Kilannin Krysiak, Zachary L Skidmore, ..., Li Ding, Jeffery M Klco, Elaine R Mardis, Timothy J Ley, Richard K Wilson
Cell systems   ·   23 Sep 2015   ·   pubmed:26645048
Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.
Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.
Jeffery M Klco, Christopher A Miller, Malachi Griffith, Allegra Petti, David H Spencer, ..., Daniel C Link, Elaine R Mardis, John F DiPersio, Richard K Wilson, Timothy J Ley
JAMA   ·   25 Aug 2015   ·   pubmed:26305651
Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma.
Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma.
Angela C Hirbe, Sonika Dahiya, Christopher A Miller, Tiandao Li, Robert S Fulton, ..., Haley J Abel, Melike Pekmezci, Arie Perry, Timothy J Ley, David H Gutmann
Clinical cancer research : an official journal of the American Association for Cancer Research   ·   29 Apr 2015   ·   pubmed:25925892
Genetic heterogeneity of induced pluripotent stem cells: results from 24 clones derived from a single C57BL/6 mouse.
Genetic heterogeneity of induced pluripotent stem cells: results from 24 clones derived from a single C57BL/6 mouse.
Cheng Li, Jeffery M Klco, Nichole M Helton, Daniel R George, Jacqueline L Mudd, ..., Robert Fulton, Michelle O'Laughlin, Catrina Fronick, Richard K Wilson, Timothy J Ley
PloS one   ·   23 Mar 2015   ·   pubmed:25799070
Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing.
Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing.
A L Young, T N Wong, A E O Hughes, S E Heath, T J Ley, D C Link, T E Druley
Leukemia   ·   03 Feb 2015   ·   pubmed:25644247
Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells.
Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells.
D H Spencer, M A Young, T L Lamprecht, N M Helton, R Fulton, ..., R T Demeter, C A Miller, J M Klco, R K Wilson, T J Ley
Leukemia   ·   20 Jan 2015   ·   pubmed:25600023

2014

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.
Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.
Terrence N Wong, Giridharan Ramsingh, Andrew L Young, Christopher A Miller, Waseem Touma, ..., Timothy A Graubert, Timothy J Ley, Todd Druley, Daniel C Link, Richard K Wilson
Nature   ·   08 Dec 2014   ·   pubmed:25487151
Clonal architectures and driver mutations in metastatic melanomas.
Clonal architectures and driver mutations in metastatic melanomas.
Li Ding, Minjung Kim, Krishna L Kanchi, Nathan D Dees, Charles Lu, ..., Ryan C Fields, Timothy J Ley, James J Mulé, Richard K Wilson, Jeffrey S Weber
PloS one   ·   13 Nov 2014   ·   pubmed:25393105
Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.
Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.
Elise Peterson Lu, Michael McLellan, Li Ding, Robert Fulton, Elaine R Mardis, ..., John F DiPersio, Daniel C Link, Matthew J Walter, Timothy J Ley, Timothy A Graubert
Blood   ·   27 Oct 2014   ·   pubmed:25349173
Age-related mutations associated with clonal hematopoietic expansion and malignancies.
Age-related mutations associated with clonal hematopoietic expansion and malignancies.
Mingchao Xie, Charles Lu, Jiayin Wang, Michael D McLellan, Kimberly J Johnson, ..., John F Dipersio, Feng Chen, Richard K Wilson, Timothy J Ley, Li Ding
Nature medicine   ·   19 Oct 2014   ·   pubmed:25326804
U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing.
U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing.
T Okeyo-Owuor, B S White, R Chatrikhi, D R Mohan, S Kim, ..., K M Laird, C L Kielkopf, T J Ley, M J Walter, T A Graubert
Leukemia   ·   14 Oct 2014   ·   pubmed:25311244
Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia.
Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia.
E K Engle, D A C Fisher, C A Miller, M D McLellan, R S Fulton, D M Moore, R K Wilson, T J Ley, S T Oh
Leukemia   ·   25 Sep 2014   ·   pubmed:25252869
SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution.
SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution.
Christopher A Miller, Brian S White, Nathan D Dees, Malachi Griffith, John S Welch, ..., John F DiPersio, Timothy J Ley, Elaine R Mardis, Richard K Wilson, Li Ding
PLoS computational biology   ·   07 Aug 2014   ·   pubmed:25102416
Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro.
Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro.
S M Sarkaria, M J Christopher, J M Klco, T J Ley
Leukemia   ·   31 Jul 2014   ·   pubmed:25092143
Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing.
Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing.
Andrew E O Hughes, Vincent Magrini, Ryan Demeter, Christopher A Miller, Robert Fulton, ..., Elaine R Mardis, Richard K Wilson, Timothy J Ley, Matthew J Walter, Timothy A Graubert
PLoS genetics   ·   10 Jul 2014   ·   pubmed:25010716
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers.
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers.
David A Russler-Germain, David H Spencer, Margaret A Young, Tamara L Lamprecht, Christopher A Miller, ..., Matthew R Meyer, Petra Erdmann-Gilmore, R Reid Townsend, Richard K Wilson, Timothy J Ley
Cancer cell   ·   20 Mar 2014   ·   pubmed:24656771
Functional heterogeneity of genetically defined subclones in acute myeloid leukemia.
Functional heterogeneity of genetically defined subclones in acute myeloid leukemia.
Jeffery M Klco, David H Spencer, Christopher A Miller, Malachi Griffith, Tamara L Lamprecht, ..., Matthew J Walter, Elaine R Mardis, John F Dipersio, Richard K Wilson, Timothy J Ley
Cancer cell   ·   06 Mar 2014   ·   pubmed:24613412

2013

Mutational landscape and significance across 12 major cancer types.
Mutational landscape and significance across 12 major cancer types.
Cyriac Kandoth, Michael D McLellan, Fabio Vandin, Kai Ye, Beifang Niu, ..., Michael C Wendl, Timothy J Ley, Richard K Wilson, Benjamin J Raphael, Li Ding
Nature   ·   17 Oct 2013   ·   pubmed:24132290
DGIdb: mining the druggable genome.
DGIdb: mining the druggable genome.
Malachi Griffith, Obi L Griffith, Adam C Coffman, James V Weible, Josh F McMichael, ..., David J Dooling, Scott M Smith, Timothy J Ley, Elaine R Mardis, Richard K Wilson
Nature methods   ·   13 Oct 2013   ·   pubmed:24122041
Genomic landscapes and clonality of de novo AML.
Genomic landscapes and clonality of de novo AML.
Christopher A Miller, Richard K Wilson, Timothy J Ley
The New England journal of medicine   ·   10 Oct 2013   ·   pubmed:24106950
Acquired copy number alterations of miRNA genes in acute myeloid leukemia are uncommon.
Acquired copy number alterations of miRNA genes in acute myeloid leukemia are uncommon.
Giridharan Ramsingh, Meagan A Jacoby, Jin Shao, Rigoberto E De Jesus Pizzaro, Dong Shen, Maria Trissal, Angela H Getz, Timothy J Ley, Matthew J Walter, Daniel C Link
Blood   ·   05 Sep 2013   ·   pubmed:24009227
BreakTrans: uncovering the genomic architecture of gene fusions.
BreakTrans: uncovering the genomic architecture of gene fusions.
Ken Chen, Nicholas E Navin, Yong Wang, Heather K Schmidt, John W Wallis, ..., Elaine R Mardis, Timothy J Ley, Charles M Perou, Richard K Wilson, Li Ding
Genome biology   ·   23 Aug 2013   ·   pubmed:23972288
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.
Timothy J Ley, Christopher Miller, Li Ding, Benjamin J Raphael, Andrew J Mungall, ..., Margi Sheth, Heidi J Sofia, Liming Yang, James R Downing, Greg Eley
The New England journal of medicine   ·   01 May 2013   ·   pubmed:23634996
Notch signaling in acute promyelocytic leukemia.
Notch signaling in acute promyelocytic leukemia.
Nicole R Grieselhuber, Jeffery M Klco, Angela M Verdoni, Tamara Lamprecht, Shawn M Sarkaria, Lukas D Wartman, Timothy J Ley
Leukemia   ·   04 Mar 2013   ·   pubmed:23455394
Clonal diversity of recurrently mutated genes in myelodysplastic syndromes.
Clonal diversity of recurrently mutated genes in myelodysplastic syndromes.
M J Walter, D Shen, J Shao, L Ding, B S White, ..., J F DiPersio, E Mardis, T J Ley, R K Wilson, T A Graubert
Leukemia   ·   27 Feb 2013   ·   pubmed:23443460
Genomic impact of transient low-dose decitabine treatment on primary AML cells.
Genomic impact of transient low-dose decitabine treatment on primary AML cells.
Jeffery M Klco, David H Spencer, Tamara L Lamprecht, Shawn M Sarkaria, Todd Wylie, ..., Matthew R Meyer, R Reid Townsend, Richard K Wilson, Elaine R Mardis, Timothy J Ley
Blood   ·   07 Jan 2013   ·   pubmed:23297133

2012

An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.
An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.
Tanja A Gruber, Amanda Larson Gedman, Jinghui Zhang, Cary S Koss, Suresh Marada, ..., Jeffrey E Rubnitz, Ching-Hon Pui, Elaine R Mardis, Richard K Wilson, James R Downing
Cancer cell   ·   13 Nov 2012   ·   pubmed:23153540
Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice.
Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice.
Lukas D Wartman, John S Welch, Geoffrey L Uy, Jeffery M Klco, Tamara Lamprecht, Nobish Varghese, Rakesh Nagarajan, Timothy J Ley
PloS one   ·   08 Oct 2012   ·   pubmed:23056333
The origin and evolution of mutations in acute myeloid leukemia.
The origin and evolution of mutations in acute myeloid leukemia.
John S Welch, Timothy J Ley, Daniel C Link, Christopher A Miller, David E Larson, ..., Timothy A Graubert, John F DiPersio, Li Ding, Elaine R Mardis, Richard K Wilson
Cell   ·   20 Jul 2012   ·   pubmed:22817890
Whole-genome analysis informs breast cancer response to aromatase inhibition.
Whole-genome analysis informs breast cancer response to aromatase inhibition.
Matthew J Ellis, Li Ding, Dong Shen, Jingqin Luo, Vera J Suman, ..., Timothy J Ley, David Piwnica-Worms, Joshua M Stuart, Richard K Wilson, Elaine R Mardis
Nature   ·   10 Jun 2012   ·   pubmed:22722193
The Pediatric Cancer Genome Project.
The Pediatric Cancer Genome Project.
James R Downing, Richard K Wilson, Jinghui Zhang, Elaine R Mardis, Ching-Hon Pui, Li Ding, Timothy J Ley, William E Evans
Nature genetics   ·   29 May 2012   ·   pubmed:22641210
BreakFusion: targeted assembly-based identification of gene fusions in whole transcriptome paired-end sequencing data.
BreakFusion: targeted assembly-based identification of gene fusions in whole transcriptome paired-end sequencing data.
Ken Chen, John W Wallis, Cyriac Kandoth, Joelle M Kalicki-Veizer, Karen L Mungall, ..., Timothy J Ley, Elaine R Mardis, Richard K Wilson, John N Weinstein, Li Ding
Bioinformatics (Oxford, England)   ·   04 May 2012   ·   pubmed:22563071
Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells.
Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells.
Margaret A Young, David E Larson, Chiao-Wang Sun, Daniel R George, Li Ding, ..., Mark S Sands, Elaine R Mardis, Richard K Wilson, Tim M Townes, Timothy J Ley
Cell stem cell   ·   26 Apr 2012   ·   pubmed:22542160
Clonal architecture of secondary acute myeloid leukemia.
Clonal architecture of secondary acute myeloid leukemia.
Matthew J Walter, Dong Shen, Li Ding, Jin Shao, Daniel C Koboldt, ..., Daniel C Link, Elaine R Mardis, Timothy J Ley, Richard K Wilson, Timothy A Graubert
The New England journal of medicine   ·   14 Mar 2012   ·   pubmed:22417201
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing.
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing.
Li Ding, Timothy J Ley, David E Larson, Christopher A Miller, Daniel C Koboldt, ..., Matthew J Walter, Timothy A Graubert, Elaine R Mardis, Richard K Wilson, John F DiPersio
Nature   ·   11 Jan 2012   ·   pubmed:22237025
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.
Jinghui Zhang, Li Ding, Linda Holmfeldt, Gang Wu, Sue L Heatley, ..., Timothy J Ley, Elaine R Mardis, Richard K Wilson, James R Downing, Charles G Mullighan
Nature   ·   11 Jan 2012   ·   pubmed:22237106

2011

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.
Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.
Timothy A Graubert, Dong Shen, Li Ding, Theresa Okeyo-Owuor, Cara L Lunn, ..., John F DiPersio, Elaine R Mardis, Timothy J Ley, Richard K Wilson, Matthew J Walter
Nature genetics   ·   11 Dec 2011   ·   pubmed:22158538
SomaticSniper: identification of somatic point mutations in whole genome sequencing data.
SomaticSniper: identification of somatic point mutations in whole genome sequencing data.
David E Larson, Christopher C Harris, Ken Chen, Daniel C Koboldt, Travis E Abbott, David J Dooling, Timothy J Ley, Elaine R Mardis, Richard K Wilson, Li Ding
Bioinformatics (Oxford, England)   ·   06 Dec 2011   ·   pubmed:22155872
Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML.
Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML.
Daniel C Link, Laura G Schuettpelz, Dong Shen, Jinling Wang, Matthew J Walter, ..., Li Ding, Timothy J Ley, Gerard P Zambetti, Richard K Wilson, Elaine R Mardis
JAMA   ·   20 Apr 2011   ·   pubmed:21505135
Use of whole-genome sequencing to diagnose a cryptic fusion oncogene.
Use of whole-genome sequencing to diagnose a cryptic fusion oncogene.
John S Welch, Peter Westervelt, Li Ding, David E Larson, Jeffery M Klco, ..., Timothy A Graubert, John F DiPersio, Elaine R Mardis, Timothy J Ley, Richard K Wilson
JAMA   ·   20 Apr 2011   ·   pubmed:21505136
PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice.
PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice.
John S Welch, Wenlin Yuan, Timothy J Ley
The Journal of clinical investigation   ·   01 Apr 2011   ·   pubmed:21364283
Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression.
Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression.
Lukas D Wartman, David E Larson, Zhifu Xiang, Li Ding, Ken Chen, ..., Timothy A Graubert, Michael H Tomasson, Elaine R Mardis, Richard K Wilson, Timothy J Ley
The Journal of clinical investigation   ·   23 Mar 2011   ·   pubmed:21436584
Recurrent DNMT3A mutations in patients with myelodysplastic syndromes.
Recurrent DNMT3A mutations in patients with myelodysplastic syndromes.
M J Walter, L Ding, D Shen, J Shao, M Grillot, ..., J F DiPersio, E R Mardis, R K Wilson, T J Ley, T A Graubert
Leukemia   ·   18 Mar 2011   ·   pubmed:21415852

2010

Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.
Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.
John S Welch, Jeffery M Klco, Nobish Varghese, Rakesh Nagarajan, Timothy J Ley
Blood   ·   29 Dec 2010   ·   pubmed:21190992
DNMT3A mutations in acute myeloid leukemia.
DNMT3A mutations in acute myeloid leukemia.
Timothy J Ley, Li Ding, Matthew J Walter, Michael D McLellan, Tamara Lamprecht, ..., Daniel C Link, Timothy A Graubert, John F DiPersio, Elaine R Mardis, Richard K Wilson
The New England journal of medicine   ·   10 Nov 2010   ·   pubmed:21067377
Next-generation sequencing identifies the natural killer cell microRNA transcriptome.
Next-generation sequencing identifies the natural killer cell microRNA transcriptome.
Todd A Fehniger, Todd Wylie, Elizabeth Germino, Jeffrey W Leong, Vincent J Magrini, ..., Rakesh Nagarajan, Giridharan Ramsingh, Daniel C Link, Timothy J Ley, Elaine R Mardis
Genome research   ·   08 Oct 2010   ·   pubmed:20935160
Complete characterization of the microRNAome in a patient with acute myeloid leukemia.
Complete characterization of the microRNAome in a patient with acute myeloid leukemia.
Giridharan Ramsingh, Daniel C Koboldt, Maria Trissal, Katherine B Chiappinelli, Todd Wylie, ..., Richard K Wilson, Li Ding, Timothy J Ley, Elaine R Mardis, Daniel C Link
Blood   ·   28 Sep 2010   ·   pubmed:20876853
A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia.
A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia.
Geoffrey L Uy, Andrew A Lane, John S Welch, Nicole R Grieselhuber, Jacqueline E Payton, Timothy J Ley
Blood   ·   20 Jul 2010   ·   pubmed:20647568
Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.
Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.
Zhifu Xiang, Hui Luo, Jacqueline E Payton, Jennifer Cain, Timothy J Ley, Joseph T Opferman, Michael H Tomasson
The Journal of clinical investigation   ·   17 May 2010   ·   pubmed:20484815
International network of cancer genome projects.
International network of cancer genome projects.
Thomas J Hudson, Warwick Anderson, Axel Artez, Anna D Barker, Cindy Bell, ..., Paul T Spellman, Hendrik G Stunnenberg, Brandon J Wainwright, Richard K Wilson, Huanming Yang
Nature   ·   15 Apr 2010   ·   pubmed:20393554
Genome remodelling in a basal-like breast cancer metastasis and xenograft.
Genome remodelling in a basal-like breast cancer metastasis and xenograft.
Li Ding, Matthew J Ellis, Shunqiang Li, David E Larson, Ken Chen, ..., Rebecca Aft, Mark Watson, Timothy J Ley, Richard K Wilson, Elaine R Mardis
Nature   ·   15 Apr 2010   ·   pubmed:20393555
POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature.
POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature.
J M Fortier, J E Payton, P Cahan, T J Ley, M J Walter, T A Graubert
Leukemia   ·   08 Apr 2010   ·   pubmed:20376082
Latent herpesvirus infection arms NK cells.
Latent herpesvirus infection arms NK cells.
Douglas W White, Catherine R Keppel, Stephanie E Schneider, Tiffany A Reese, James Coder, Jacqueline E Payton, Timothy J Ley, Herbert W Virgin, Todd A Fehniger
Blood   ·   04 Feb 2010   ·   pubmed:20139098

2009

Granzyme B is not required for regulatory T cell-mediated suppression of graft-versus-host disease.
Granzyme B is not required for regulatory T cell-mediated suppression of graft-versus-host disease.
Sheng F Cai, Xuefang Cao, Anjum Hassan, Todd A Fehniger, Timothy J Ley
Blood   ·   13 Nov 2009   ·   pubmed:19965675
Next-generation sequencing of cancer genomes: back to the future.
Next-generation sequencing of cancer genomes: back to the future.
Matthew J Walter, Timothy A Graubert, John F Dipersio, Elaine R Mardis, Richard K Wilson, Timothy J Ley
Personalized medicine   ·   01 Nov 2009   ·   pubmed:20161678
Interleukin 12 stimulates IFN-gamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance.
Interleukin 12 stimulates IFN-gamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance.
Xuefang Cao, Karen Leonard, Lynne I Collins, Sheng F Cai, Joshua C Mayer, Jacqueline E Payton, Michael J Walter, David Piwnica-Worms, Robert D Schreiber, Timothy J Ley
Cancer research   ·   20 Oct 2009   ·   pubmed:19843867
BreakDancer: an algorithm for high-resolution mapping of genomic structural variation.
BreakDancer: an algorithm for high-resolution mapping of genomic structural variation.
Ken Chen, John W Wallis, Michael D McLellan, David E Larson, Joelle M Kalicki, ..., Robert S Fulton, Timothy J Ley, Richard K Wilson, Li Ding, Elaine R Mardis
Nature methods   ·   09 Aug 2009   ·   pubmed:19668202
Recurring mutations found by sequencing an acute myeloid leukemia genome.
Recurring mutations found by sequencing an acute myeloid leukemia genome.
Elaine R Mardis, Li Ding, David J Dooling, David E Larson, Michael D McLellan, ..., Matthew J Walter, Timothy A Graubert, John F DiPersio, Richard K Wilson, Timothy J Ley
The New England journal of medicine   ·   05 Aug 2009   ·   pubmed:19657110
Acquired copy number alterations in adult acute myeloid leukemia genomes.
Acquired copy number alterations in adult acute myeloid leukemia genomes.
Matthew J Walter, Jacqueline E Payton, Rhonda E Ries, William D Shannon, Hrishikesh Deshmukh, ..., Elaine R Mardis, Daniel C Link, Timothy A Graubert, John F DiPersio, Timothy J Ley
Proceedings of the National Academy of Sciences of the United States of America   ·   27 Jul 2009   ·   pubmed:19651600
High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples.
High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples.
Jacqueline E Payton, Nicole R Grieselhuber, Li-Wei Chang, Mark Murakami, Gary K Geiss, Daniel C Link, Rakesh Nagarajan, Mark A Watson, Timothy J Ley
The Journal of clinical investigation   ·   18 May 2009   ·   pubmed:19451695
Differential expression of granzyme B and C in murine cytotoxic lymphocytes.
Differential expression of granzyme B and C in murine cytotoxic lymphocytes.
Sheng F Cai, Todd A Fehniger, Xuefang Cao, Joshua C Mayer, Joel D Brune, Anthony R French, Timothy J Ley
Journal of immunology (Baltimore, Md. : 1950)   ·   15 May 2009   ·   pubmed:19414782

2008

Sociology. The gender gap in NIH grant applications.
Sociology. The gender gap in NIH grant applications.
Timothy J Ley, Barton H Hamilton
Science (New York, N.Y.)   ·   05 Dec 2008   ·   pubmed:19056961
Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100.
Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100.
Bruno Nervi, Pablo Ramirez, Michael P Rettig, Geoffrey L Uy, Matthew S Holt, ..., Julie L Prior, David Piwnica-Worms, Gary Bridger, Timothy J Ley, John F DiPersio
Blood   ·   02 Dec 2008   ·   pubmed:19050309
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.
Timothy J Ley, Elaine R Mardis, Li Ding, Bob Fulton, Michael D McLellan, ..., Matthew J Walter, Daniel C Link, Timothy A Graubert, John F DiPersio, Richard K Wilson
Nature   ·   06 Nov 2008   ·   pubmed:18987736
Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice.
Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice.
Ryan K Funk, Taylor J Maxwell, Masayo Izumi, Deepa Edwin, Friederike Kreisel, Timothy J Ley, James M Cheverud, Timothy A Graubert
Blood   ·   13 Jun 2008   ·   pubmed:18552208
wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data.
wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data.
Patrick Cahan, Laura E Godfrey, Peggy S Eis, Todd A Richmond, Rebecca R Selzer, Michael Brent, Howard L McLeod, Timothy J Ley, Timothy A Graubert
Nucleic acids research   ·   11 Mar 2008   ·   pubmed:18334530
Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia.
Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia.
Li Wei Chang, Jacqueline E Payton, Wenlin Yuan, Timothy J Ley, Rakesh Nagarajan, Gary D Stormo
Genome biology   ·   21 Feb 2008   ·   pubmed:18291030
Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.
Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.
Michael H Tomasson, Zhifu Xiang, Richard Walgren, Yu Zhao, Yumi Kasai, ..., Rakesh Nagarajan, Clara D Bloomfield, Elaine R Mardis, Richard K Wilson, Timothy J Ley
Blood   ·   12 Feb 2008   ·   pubmed:18270328

2007

Identification of somatic JAK1 mutations in patients with acute myeloid leukemia.
Identification of somatic JAK1 mutations in patients with acute myeloid leukemia.
Zhifu Xiang, Yu Zhao, Vesselin Mitaksov, Daved H Fremont, Yumi Kasai, ..., Rakesh Nagarajan, Elaine R Mardis, Richard K Wilson, Timothy J Ley, Michael H Tomasson
Blood   ·   26 Dec 2007   ·   pubmed:18160671
Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance.
Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance.
Xuefang Cao, Sheng F Cai, Todd A Fehniger, Jiling Song, Lynne I Collins, David R Piwnica-Worms, Timothy J Ley
Immunity   ·   04 Oct 2007   ·   pubmed:17919943
Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs.
Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs.
Todd A Fehniger, Sheng F Cai, Xuefang Cao, Andrew J Bredemeyer, Rachel M Presti, Anthony R French, Timothy J Ley
Immunity   ·   31 May 2007   ·   pubmed:17540585
Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia.
Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia.
Daniel C Link, Ghada Kunter, Yumi Kasai, Yu Zhao, Tracie Miner, ..., William Shannon, Jack Baty, Elaine R Mardis, Richard K Wilson, Timothy J Ley
Blood   ·   09 May 2007   ·   pubmed:17494858

2006

A high-resolution map of segmental DNA copy number variation in the mouse genome.
A high-resolution map of segmental DNA copy number variation in the mouse genome.
Timothy A Graubert, Patrick Cahan, Deepa Edwin, Rebecca R Selzer, Todd A Richmond, ..., William D Shannon, Xia Li, Howard L McLeod, James M Cheverud, Timothy J Ley
PLoS genetics   ·   22 Nov 2006   ·   pubmed:17206864
Expression of a bcr-1 isoform of RARalpha-PML does not affect the penetrance of acute promyelocytic leukemia or the acquisition of an interstitial deletion on mouse chromosome 2.
Expression of a bcr-1 isoform of RARalpha-PML does not affect the penetrance of acute promyelocytic leukemia or the acquisition of an interstitial deletion on mouse chromosome 2.
Matthew J Walter, Rhonda E Ries, Jon R Armstrong, John S Park, Elaine R Mardis, Timothy J Ley
Blood   ·   28 Sep 2006   ·   pubmed:17008533
Commonly dysregulated genes in murine APL cells.
Commonly dysregulated genes in murine APL cells.
Wenlin Yuan, Jacqueline E Payton, Matthew S Holt, Daniel C Link, Mark A Watson, John F DiPersio, Timothy J Ley
Blood   ·   28 Sep 2006   ·   pubmed:17008535
Hop cleavage and function in granzyme B-induced apoptosis.
Hop cleavage and function in granzyme B-induced apoptosis.
Andrew J Bredemeyer, Patricia E Carrigan, Todd A Fehniger, David F Smith, Timothy J Ley
The Journal of biological chemistry   ·   27 Sep 2006   ·   pubmed:17005566
Cold shock domain family members YB-1 and MSY4 share essential functions during murine embryogenesis.
Cold shock domain family members YB-1 and MSY4 share essential functions during murine embryogenesis.
Zhi Hong Lu, Jason T Books, Timothy J Ley
Molecular and cellular biology   ·   05 Sep 2006   ·   pubmed:16954378
Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease.
Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease.
Iris T Chan, Jeffery L Kutok, Ifor R Williams, Sarah Cohen, Sandra Moore, Hirokazu Shigematsu, Timothy J Ley, Koichi Akashi, Michelle M Le Beau, D Gary Gilliland
Blood   ·   04 May 2006   ·   pubmed:16675706

2005

The physician-scientist career pipeline in 2005: build it, and they will come.
The physician-scientist career pipeline in 2005: build it, and they will come.
Timothy J Ley, Leon E Rosenberg
JAMA   ·   21 Sep 2005   ·   pubmed:16174692
Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.
Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.
Matthew J Walter, John S Park, Rhonda E Ries, Steven K M Lau, Michael McLellan, Sara Jaeger, Richard K Wilson, Elaine R Mardis, Timothy J Ley
Proceedings of the National Academy of Sciences of the United States of America   ·   19 Aug 2005   ·   pubmed:16113082
Murine acute promyelocytic leukemia cells can be recognized and cleared in vivo by adaptive immune mechanisms.
Murine acute promyelocytic leukemia cells can be recognized and cleared in vivo by adaptive immune mechanisms.
Jessica L Pollock, Andrew A Lane, Kelly Schrimpf, Timothy J Ley
Haematologica   ·   01 Aug 2005   ·   pubmed:16079103
YB-1 is important for late-stage embryonic development, optimal cellular stress responses, and the prevention of premature senescence.
YB-1 is important for late-stage embryonic development, optimal cellular stress responses, and the prevention of premature senescence.
Zhi Hong Lu, Jason T Books, Timothy J Ley
Molecular and cellular biology   ·   01 Jun 2005   ·   pubmed:15899865
Retrospective: Stanley Joel Korsmeyer (1950-2005).
Retrospective: Stanley Joel Korsmeyer (1950-2005).
Timothy J Ley
Science (New York, N.Y.)   ·   06 May 2005   ·   pubmed:15879200
Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions.
Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions.
Paula A Revell, William J Grossman, Dori A Thomas, Xuefang Cao, Rajesh Behl, Jane A Ratner, Zhi Hong Lu, Timothy J Ley
Journal of immunology (Baltimore, Md. : 1950)   ·   15 Feb 2005   ·   pubmed:15699143
Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells.
Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells.
Andrew A Lane, Timothy J Ley
Molecular and cellular biology   ·   01 Jan 2005   ·   pubmed:15601827
Use of protease proteomics to discover granzyme B substrates.
Use of protease proteomics to discover granzyme B substrates.
Andrew J Bredemeyer, R Reid Townsend, Timothy J Ley
Immunologic research   ·   01 Jan 2005   ·   pubmed:16106065

2004

Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans.
Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans.
Christine T N Pham, Jennifer L Ivanovich, Sofia Z Raptis, Barbara Zehnbauer, Timothy J Ley
Journal of immunology (Baltimore, Md. : 1950)   ·   15 Dec 2004   ·   pubmed:15585850
Expression profiling of murine acute promyelocytic leukemia cells reveals multiple model-dependent progression signatures.
Expression profiling of murine acute promyelocytic leukemia cells reveals multiple model-dependent progression signatures.
Matthew J Walter, John S Park, Steven K M Lau, Xia Li, Andrew A Lane, Rakesh Nagarajan, William D Shannon, Timothy J Ley
Molecular and cellular biology   ·   01 Dec 2004   ·   pubmed:15572690
Granzymes and caspase 3 play important roles in control of gammaherpesvirus latency.
Granzymes and caspase 3 play important roles in control of gammaherpesvirus latency.
Joy Loh, Dori A Thomas, Paula A Revell, Timothy J Ley, Herbert W Virgin
Journal of virology   ·   01 Nov 2004   ·   pubmed:15507639
Human T regulatory cells can use the perforin pathway to cause autologous target cell death.
Human T regulatory cells can use the perforin pathway to cause autologous target cell death.
William J Grossman, James W Verbsky, Winfried Barchet, Marco Colonna, John P Atkinson, Timothy J Ley
Immunity   ·   01 Oct 2004   ·   pubmed:15485635
Granzymes A and B are not expressed in human neutrophils.
Granzymes A and B are not expressed in human neutrophils.
William J Grossman, Timothy J Ley
Blood   ·   01 Aug 2004   ·   pubmed:15265800
A proteomic approach for the discovery of protease substrates.
A proteomic approach for the discovery of protease substrates.
Andrew J Bredemeyer, Renate M Lewis, James P Malone, Alan E Davis, Julia Gross, R Reid Townsend, Timothy J Ley
Proceedings of the National Academy of Sciences of the United States of America   ·   27 Jul 2004   ·   pubmed:15280543
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells.
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells.
William J Grossman, James W Verbsky, Benjamin L Tollefsen, Claudia Kemper, John P Atkinson, Timothy J Ley
Blood   ·   06 Jul 2004   ·   pubmed:15238416

2003

1998 ASCI Presidential Address.
1998 ASCI Presidential Address.
Timothy J Ley
The Journal of clinical investigation   ·   01 Dec 2003   ·   pubmed:14702962
A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes.
A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes.
Timothy J Ley, Patrick J Minx, Matthew J Walter, Rhonda E Ries, Hui Sun, ..., Michael A Caligiuri, Clara D Bloomfield, Jeffrey D Milbrandt, Elaine R Mardis, Richard K Wilson
Proceedings of the National Academy of Sciences of the United States of America   ·   12 Nov 2003   ·   pubmed:14614138
The orphan granzymes of humans and mice.
The orphan granzymes of humans and mice.
William J Grossman, Paula A Revell, Zhi Hong Lu, Hillary Johnson, Andrew J Bredemeyer, Timothy J Ley
Current opinion in immunology   ·   01 Oct 2003   ·   pubmed:14499263
High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression.
High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression.
Peter Westervelt, Andrew A Lane, Jessica L Pollock, Kristie Oldfather, Matthew S Holt, Drazen B Zimonjic, Nicholas C Popescu, John F DiPersio, Timothy J Ley
Blood   ·   15 May 2003   ·   pubmed:12750176
Long targeting arms do not increase the efficiency of homologous recombination in the beta-globin locus of murine embryonic stem cells.
Long targeting arms do not increase the efficiency of homologous recombination in the beta-globin locus of murine embryonic stem cells.
Zhi Hong Lu, Jason T Books, Richard M Kaufman, Timothy J Ley
Blood   ·   01 May 2003   ·   pubmed:12730107
Mutational profiling in the human genome.
Mutational profiling in the human genome.
R K Wilson, T J Ley, F S Cole, J D Milbrandt, S Clifton, ..., P Minx, H Sun, M McLellan, C Pohl, E R Mardis
Cold Spring Harbor symposia on quantitative biology   ·   01 Jan 2003   ·   pubmed:15338599

2002

Cell death induced by granzyme C.
Cell death induced by granzyme C.
Hillary Johnson, Luca Scorrano, Stanley J Korsmeyer, Timothy J Ley
Blood   ·   19 Dec 2002   ·   pubmed:12515723
Adaptive immunity cooperates with liposomal all-trans-retinoic acid (ATRA) to facilitate long-term molecular remissions in mice with acute promyelocytic leukemia.
Adaptive immunity cooperates with liposomal all-trans-retinoic acid (ATRA) to facilitate long-term molecular remissions in mice with acute promyelocytic leukemia.
Peter Westervelt, Jessica L Pollock, Kristie M Oldfather, Matthew J Walter, Margaret K Ma, Anthony Williams, John F DiPersio, Timothy J Ley
Proceedings of the National Academy of Sciences of the United States of America   ·   20 Jun 2002   ·   pubmed:12077315
PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model.
PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model.
Louise M Kelly, Jeffrey L Kutok, Ifor R Williams, Christina L Boulton, Sonia M Amaral, David P Curley, Timothy J Ley, D Gary Gilliland
Proceedings of the National Academy of Sciences of the United States of America   ·   11 Jun 2002   ·   pubmed:12060771
Removing career obstacles for young physician-scientists -- loan-repayment programs.
Removing career obstacles for young physician-scientists -- loan-repayment programs.
Timothy J Ley, Leon E Rosenberg
The New England journal of medicine   ·   31 Jan 2002   ·   pubmed:11821517

2001

Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.
Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.
D A Thomas, L Scorrano, G V Putcha, S J Korsmeyer, T J Ley
Proceedings of the National Academy of Sciences of the United States of America   ·   18 Dec 2001   ·   pubmed:11752447
Lymphocyte-mediated cytotoxicity.
Lymphocyte-mediated cytotoxicity.
John H Russell, Timothy J Ley
Annual review of immunology   ·   04 Oct 2001   ·   pubmed:11861606
Sudden death among patients with acute promyelocytic leukemia treated with arsenic trioxide.
Sudden death among patients with acute promyelocytic leukemia treated with arsenic trioxide.
P Westervelt, R A Brown, D R Adkins, H Khoury, P Curtin, D Hurd, S M Luger, M K Ma, T J Ley, J F DiPersio
Blood   ·   15 Jul 2001   ·   pubmed:11435292
Mouse models of acute promyelocytic leukemia.
Mouse models of acute promyelocytic leukemia.
J L Pollock, P Westervelt, M J Walter, A A Lane, T J Ley
Current opinion in hematology   ·   01 Jul 2001   ·   pubmed:11561157
Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice.
Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice.
P J Wolters, C T Pham, D J Muilenburg, T J Ley, G H Caughey
The Journal of biological chemistry   ·   23 Feb 2001   ·   pubmed:11279033

2000

Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice.
Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice.
D B Zimonjic, J L Pollock, P Westervelt, N C Popescu, T J Ley
Proceedings of the National Academy of Sciences of the United States of America   ·   21 Nov 2000   ·   pubmed:11087871
Independent formation of DnaseI hypersensitive sites in the murine beta-globin locus control region.
Independent formation of DnaseI hypersensitive sites in the murine beta-globin locus control region.
M A Bender, M G Mehaffey, A Telling, B Hug, T J Ley, M Groudine, S Fiering
Blood   ·   01 Jun 2000   ·   pubmed:10828050
DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis.
DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis.
D A Thomas, C Du, M Xu, X Wang, T J Ley
Immunity   ·   01 Jun 2000   ·   pubmed:10894162
The physician-scientist: career issues and challenges at the year 2000.
The physician-scientist: career issues and challenges at the year 2000.
T R Zemlo, H H Garrison, N C Partridge, T J Ley
FASEB journal : official publication of the Federation of American Societies for Experimental Biology   ·   01 Feb 2000   ·   pubmed:10657979
Deletions within the mouse beta-globin locus control region preferentially reduce beta(min) globin gene expression.
Deletions within the mouse beta-globin locus control region preferentially reduce beta(min) globin gene expression.
R Alami, M A Bender, Y Q Feng, S N Fiering, B A Hug, T J Ley, M Groudine, E E Bouhassira
Genomics   ·   01 Feb 2000   ·   pubmed:10704289

1999

A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia.
A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia.
J L Pollock, P Westervelt, A K Kurichety, P G Pelicci, J L Grisolano, T J Ley
Proceedings of the National Academy of Sciences of the United States of America   ·   21 Dec 1999   ·   pubmed:10611345
Normal neutrophil function in cathepsin G-deficient mice.
Normal neutrophil function in cathepsin G-deficient mice.
D M MacIvor, S D Shapiro, C T Pham, A Belaaouaj, S N Abraham, T J Ley
Blood   ·   15 Dec 1999   ·   pubmed:10590073
Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo.
Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo.
C T Pham, T J Ley
Proceedings of the National Academy of Sciences of the United States of America   ·   20 Jul 1999   ·   pubmed:10411926
Granzyme A initiates an alternative pathway for granule-mediated apoptosis.
Granzyme A initiates an alternative pathway for granule-mediated apoptosis.
S Shresta, T A Graubert, D A Thomas, S Z Raptis, T J Ley
Immunity   ·   01 May 1999   ·   pubmed:10367905
Seed versus soil: the importance of the target cell for transgenic models of human leukemias.
Seed versus soil: the importance of the target cell for transgenic models of human leukemias.
P Westervelt, T J Ley
Blood   ·   01 Apr 1999   ·   pubmed:10090920

1998

How do cytotoxic lymphocytes kill their targets?
How do cytotoxic lymphocytes kill their targets?
S Shresta, C T Pham, D A Thomas, T A Graubert, T J Ley
Current opinion in immunology   ·   01 Oct 1998   ·   pubmed:9794837
Augmented inflammatory responses and altered wound healing in cathepsin G-deficient mice.
Augmented inflammatory responses and altered wound healing in cathepsin G-deficient mice.
R E Abbott, C J Corral, D M MacIvor, X Lin, T J Ley, T A Mustoe
Archives of surgery (Chicago, Ill. : 1960)   ·   01 Sep 1998   ·   pubmed:9749856
Reduced beta-globin gene expression in adult mice containing deletions of locus control region 5' HS-2 or 5' HS-3.
Reduced beta-globin gene expression in adult mice containing deletions of locus control region 5' HS-2 or 5' HS-3.
T J Ley, B Hug, S Fiering, E Epner, M A Bender, M Groudine
Annals of the New York Academy of Sciences   ·   30 Jun 1998   ·   pubmed:9668526
Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene.
Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene.
T A Graubert, B A Hug, R Wesselschmidt, C L Hsieh, T M Ryan, T M Townes, T J Ley
Nucleic acids research   ·   15 Jun 1998   ·   pubmed:9611227
Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis.
Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis.
A Belaaouaj, R McCarthy, M Baumann, Z Gao, T J Ley, S N Abraham, S D Shapiro
Nature medicine   ·   01 May 1998   ·   pubmed:9585238
Production of fully active recombinant murine granzyme B in yeast.
Production of fully active recombinant murine granzyme B in yeast.
C T Pham, D A Thomas, J D Mercer, T J Ley
The Journal of biological chemistry   ·   16 Jan 1998   ·   pubmed:9430705

1997

Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation.
Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation.
T A Graubert, J F DiPersio, J H Russell, T J Ley
The Journal of clinical investigation   ·   15 Aug 1997   ·   pubmed:9259590
Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes.
Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes.
S Shresta, P Goda, R Wesselschmidt, T J Ley
The Journal of biological chemistry   ·   08 Aug 1997   ·   pubmed:9242702
Mechanisms responsible for granzyme B-independent cytotoxicity.
Mechanisms responsible for granzyme B-independent cytotoxicity.
S Shresta, J H Russell, T J Ley
Blood   ·   01 Jun 1997   ·   pubmed:9166849
Molecular cloning, chromosomal localization, and expression of murine dipeptidyl peptidase I.
Molecular cloning, chromosomal localization, and expression of murine dipeptidyl peptidase I.
C T Pham, R J Armstrong, D B Zimonjic, N C Popescu, D G Payan, T J Ley
The Journal of biological chemistry   ·   18 Apr 1997   ·   pubmed:9099719
The role of granzyme B cluster proteases in cell-mediated cytotoxicity.
The role of granzyme B cluster proteases in cell-mediated cytotoxicity.
C T Pham, T J Ley
Seminars in immunology   ·   01 Apr 1997   ·   pubmed:9194223
Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences.
Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences.
J L Grisolano, R L Wesselschmidt, P G Pelicci, T J Ley
Blood   ·   15 Jan 1997   ·   pubmed:9002938

1996

Long-range disruption of gene expression by a selectable marker cassette.
Long-range disruption of gene expression by a selectable marker cassette.
C T Pham, D M MacIvor, B A Hug, J W Heusel, T J Ley
Proceedings of the National Academy of Sciences of the United States of America   ·   12 Nov 1996   ·   pubmed:8917549
Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation.
Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation.
A J Darmon, T J Ley, D W Nicholson, R C Bleackley
The Journal of biological chemistry   ·   06 Sep 1996   ·   pubmed:8702964
Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3.
Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3.
B A Hug, R L Wesselschmidt, S Fiering, M A Bender, E Epner, M Groudine, T J Ley
Molecular and cellular biology   ·   01 Jun 1996   ·   pubmed:8649401
How do lymphocytes kill tumor cells?
How do lymphocytes kill tumor cells?
T A Graubert, T J Ley
Clinical cancer research : an official journal of the American Association for Cancer Research   ·   01 May 1996   ·   pubmed:9816231
Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice.
Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice.
J M Shipley, R L Wesselschmidt, D K Kobayashi, T J Ley, S D Shapiro
Proceedings of the National Academy of Sciences of the United States of America   ·   30 Apr 1996   ·   pubmed:8632994
The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection.
The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection.
T A Graubert, J H Russell, T J Ley
Blood   ·   15 Feb 1996   ·   pubmed:8608209
Regulation of azurophil granule-associated serine protease genes during myelopoiesis.
Regulation of azurophil granule-associated serine protease genes during myelopoiesis.
J L Grisolano, T J Ley
Current opinion in hematology   ·   01 Jan 1996   ·   pubmed:9372052

1995

An intramolecular triplex in the human gamma-globin 5'-flanking region is altered by point mutations associated with hereditary persistence of fetal hemoglobin.
An intramolecular triplex in the human gamma-globin 5'-flanking region is altered by point mutations associated with hereditary persistence of fetal hemoglobin.
A Bacolla, M J Ulrich, J E Larson, T J Ley, R D Wells
The Journal of biological chemistry   ·   13 Oct 1995   ·   pubmed:7592674
Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.
Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.
S Fiering, E Epner, K Robinson, Y Zhuang, A Telling, M Hu, D I Martin, T Enver, T J Ley, M Groudine
Genes & development   ·   15 Sep 1995   ·   pubmed:7557375
Granzyme B plays a critical role in cytotoxic lymphocyte-induced apoptosis.
Granzyme B plays a critical role in cytotoxic lymphocyte-induced apoptosis.
S Shresta, J W Heusel, D M Macivor, R L Wesselschmidt, J H Russell, T J Ley
Immunological reviews   ·   01 Aug 1995   ·   pubmed:7493755
Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.
Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.
S Shresta, D M MacIvor, J W Heusel, J H Russell, T J Ley
Proceedings of the National Academy of Sciences of the United States of America   ·   06 Jun 1995   ·   pubmed:7777569
Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.
Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.
W J Grossman, J T Kimata, F H Wong, M Zutter, T J Ley, L Ratner
Proceedings of the National Academy of Sciences of the United States of America   ·   14 Feb 1995   ·   pubmed:7862633

1994

Early myeloid cell-specific expression of the human cathepsin G gene in transgenic mice.
Early myeloid cell-specific expression of the human cathepsin G gene in transgenic mice.
J L Grisolano, G M Sclar, T J Ley
Proceedings of the National Academy of Sciences of the United States of America   ·   13 Sep 1994   ·   pubmed:8090757
<a href="https://www.ncbi.nlm.nih.gov/pubmed/8188694" class="citation-image" aria-label="A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes." > <img src="" alt="A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes." loading="lazy" onerror="this.src = '/lab-website/images/fallback.svg'; this.onerror = null;" > </a>
A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes.
E M Horwitz, K A Maloney, T J Ley
The Journal of biological chemistry   ·   13 May 1994   ·   pubmed:8188694
Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.
Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.
J W Heusel, R L Wesselschmidt, S Shresta, J H Russell, T J Ley
Cell   ·   25 Mar 1994   ·   pubmed:8137431

1993

Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages.
Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages.
S D Shapiro, D K Kobayashi, T J Ley
The Journal of biological chemistry   ·   15 Nov 1993   ·   pubmed:8226919
Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene.
Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene.
J W Heusel, E M Scarpati, N A Jenkins, D J Gilbert, N G Copeland, S D Shapiro, T J Ley
Blood   ·   15 Mar 1993   ·   pubmed:8453108
The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression.
The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression.
G H Caughey, T H Schaumberg, E H Zerweck, J H Butterfield, R D Hanson, G A Silverman, T J Ley
Genomics   ·   01 Mar 1993   ·   pubmed:8468056

1992

Structure and function of the murine beta-globin locus control region 5' HS-3.
Structure and function of the murine beta-globin locus control region 5' HS-3.
B A Hug, A M Moon, T J Ley
Nucleic acids research   ·   11 Nov 1992   ·   pubmed:1454538
An intramolecular DNA triplex is disrupted by point mutations associated with hereditary persistence of fetal hemoglobin.
An intramolecular DNA triplex is disrupted by point mutations associated with hereditary persistence of fetal hemoglobin.
M J Ulrich, W J Gray, T J Ley
The Journal of biological chemistry   ·   15 Sep 1992   ·   pubmed:1382059
Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter.
Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter.
D C Link, S J Gutkind, K C Robbins, T J Ley
Oncogene   ·   01 May 1992   ·   pubmed:1373875
Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase.
Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase.
S D Shapiro, G L Griffin, D J Gilbert, N A Jenkins, N G Copeland, H G Welgus, R M Senior, T J Ley
The Journal of biological chemistry   ·   05 Mar 1992   ·   pubmed:1537850
Neutral proteinase expression by human mononuclear phagocytes: a prominent role of cellular differentiation.
Neutral proteinase expression by human mononuclear phagocytes: a prominent role of cellular differentiation.
H G Welgus, R M Senior, W C Parks, A J Kahn, T J Ley, S D Shapiro, E J Campbell
Matrix (Stuttgart, Germany). Supplement   ·   01 Jan 1992   ·   pubmed:1480061

1991

The 5'-flanking region of the human CGL-1/granzyme B gene targets expression of a reporter gene to activated T-lymphocytes in transgenic mice.
The 5'-flanking region of the human CGL-1/granzyme B gene targets expression of a reporter gene to activated T-lymphocytes in transgenic mice.
R D Hanson, G M Sclar, O Kanagawa, T J Ley
The Journal of biological chemistry   ·   25 Dec 1991   ·   pubmed:1761544
1,25-Dihydroxyvitamin D3 induces monocytic differentiation of the PLB-985 leukemic line and promotes c-fgr mRNA expression.
1,25-Dihydroxyvitamin D3 induces monocytic differentiation of the PLB-985 leukemic line and promotes c-fgr mRNA expression.
S L Perkins, D C Link, S Kling, T J Ley, S L Teitelbaum
Journal of leukocyte biology   ·   01 Nov 1991   ·   pubmed:1660912
Functional properties of the beta-globin locus control region in K562 erythroleukemia cells.
Functional properties of the beta-globin locus control region in K562 erythroleukemia cells.
A M Moon, T J Ley
Blood   ·   15 May 1991   ·   pubmed:1709381
Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2.
Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2.
J W Heusel, R D Hanson, G A Silverman, T J Ley
The Journal of biological chemistry   ·   05 Apr 1991   ·   pubmed:2007574
The pharmacology of hemoglobin switching: of mice and men.
The pharmacology of hemoglobin switching: of mice and men.
T J Ley
Blood   ·   15 Mar 1991   ·   pubmed:1705828
A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes.
A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes.
J S Gutkind, D C Link, S Katamine, P Lacal, T Miki, T J Ley, K C Robbins
Molecular and cellular biology   ·   01 Mar 1991   ·   pubmed:1847500

1990

Transcriptional activation of the human cytotoxic serine protease gene CSP-B in T lymphocytes.
Transcriptional activation of the human cytotoxic serine protease gene CSP-B in T lymphocytes.
R D Hanson, T J Ley
Molecular and cellular biology   ·   01 Nov 1990   ·   pubmed:2233710
Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions.
Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions.
A M Moon, T J Ley
Proceedings of the National Academy of Sciences of the United States of America   ·   01 Oct 1990   ·   pubmed:2217202
A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus.
A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus.
R D Hanson, P A Hohn, N C Popescu, T J Ley
Proceedings of the National Academy of Sciences of the United States of America   ·   01 Feb 1990   ·   pubmed:2300587
Developmental regulation of the human cathepsin G gene in myelomonocytic cells.
Developmental regulation of the human cathepsin G gene in myelomonocytic cells.
R D Hanson, N L Connolly, D Burnett, E J Campbell, R M Senior, T J Ley
The Journal of biological chemistry   ·   25 Jan 1990   ·   pubmed:2295643
Function of transfected globin promoters and the globin locus activator in K562 erythroleukemia cells.
Function of transfected globin promoters and the globin locus activator in K562 erythroleukemia cells.
M J Ulrich, A M Moon, T J Ley
Annals of the New York Academy of Sciences   ·   01 Jan 1990   ·   pubmed:2291547

1989

Nucleotide sequence and regulation of a human 90-kDa heat shock protein gene.
Nucleotide sequence and regulation of a human 90-kDa heat shock protein gene.
N F Rebbe, W S Hickman, T J Ley, D W Stafford, S Hickman
The Journal of biological chemistry   ·   05 Sep 1989   ·   pubmed:2768249
Genomic organization and chromosomal localization of the human cathepsin G gene.
Genomic organization and chromosomal localization of the human cathepsin G gene.
P A Hohn, N C Popescu, R D Hanson, G Salvesen, T J Ley
The Journal of biological chemistry   ·   15 Aug 1989   ·   pubmed:2569462
Analysis of epitope expression and the functional repertoire of recombinant complement receptor 2 (CR2/CD21) in mouse and human cells.
Analysis of epitope expression and the functional repertoire of recombinant complement receptor 2 (CR2/CD21) in mouse and human cells.
J C Carel, B Frazier, T J Ley, V M Holers
Journal of immunology (Baltimore, Md. : 1950)   ·   01 Aug 1989   ·   pubmed:2473114
Globin gene expression in erythroid human fetal liver cells.
Globin gene expression in erythroid human fetal liver cells.
T J Ley, K A Maloney, J I Gordon, A L Schwartz
The Journal of clinical investigation   ·   01 Mar 1989   ·   pubmed:2921315
Regulatory regions flanking the human fetal gamma-globin genes.
Regulatory regions flanking the human fetal gamma-globin genes.
H J Lin, D M Bodine, T R Rutherford, N P Anagnou, K T McDonagh, T J Ley, A W Nienhuis
Annals of the New York Academy of Sciences   ·   01 Jan 1989   ·   pubmed:2476058
Tissue-specific expression and developmental regulation of the human fgr proto-oncogene.
Tissue-specific expression and developmental regulation of the human fgr proto-oncogene.
T J Ley, N L Connolly, S Katamine, M S Cheah, R M Senior, K C Robbins
Molecular and cellular biology   ·   01 Jan 1989   ·   pubmed:2538725

1988

High-resolution analysis of the human gamma-globin gene promoter in K562 erythroleukemia cell chromatin.
High-resolution analysis of the human gamma-globin gene promoter in K562 erythroleukemia cell chromatin.
J M Gimble, E E Max, T J Ley
Blood   ·   01 Aug 1988   ·   pubmed:3165297

1987

An enhancer element lies 3' to the human A gamma globin gene.
An enhancer element lies 3' to the human A gamma globin gene.
D M Bodine, T J Ley
The EMBO journal   ·   01 Oct 1987   ·   pubmed:3691478
A transient assay system to study gamma globin gene expression in K562 cells.
A transient assay system to study gamma globin gene expression in K562 cells.
D M Bodine, T J Ley
Progress in clinical and biological research   ·   01 Jan 1987   ·   pubmed:3432267

1986

Hydroxyurea induction of hemoglobin F production in sickle cell disease: relationship between cytotoxicity and F cell production.
Hydroxyurea induction of hemoglobin F production in sickle cell disease: relationship between cytotoxicity and F cell production.
G J Dover, R K Humphries, J G Moore, T J Ley, N S Young, S Charache, A W Nienhuis
Blood   ·   01 Mar 1986   ·   pubmed:2418898
Induction of fgr proto-oncogene mRNA in B lymphocytes as a consequence of Epstein-Barr virus infection.
Induction of fgr proto-oncogene mRNA in B lymphocytes as a consequence of Epstein-Barr virus infection.
M S Cheah, T J Ley, S R Tronick, K C Robbins
Current topics in microbiology and immunology   ·   01 Jan 1986   ·   pubmed:3024916

1985

Pharmacological manipulation of fetal hemoglobin synthesis in patients with severe beta-thalassemia.
Pharmacological manipulation of fetal hemoglobin synthesis in patients with severe beta-thalassemia.
A W Nienhuis, T J Ley, R K Humphries, N S Young, G Dover
Annals of the New York Academy of Sciences   ·   01 Jan 1985   ·   pubmed:2409872
Disseminated infection caused by Cunninghamella bertholletiae in a patient with beta-thalassemia. Case report and review of the literature.
Disseminated infection caused by Cunninghamella bertholletiae in a patient with beta-thalassemia. Case report and review of the literature.
J M Sands, A M Macher, T J Ley, A W Nienhuis
Annals of internal medicine   ·   01 Jan 1985   ·   pubmed:2578267
Induction of hemoglobin F synthesis in patients with beta thalassemia.
Induction of hemoglobin F synthesis in patients with beta thalassemia.
T J Ley, A W Nienhuis
Annual review of medicine   ·   01 Jan 1985   ·   pubmed:2581500

1984

DNA methylation and regulation of the human beta-globin-like genes in mouse erythroleukemia cells containing human chromosome 11.
DNA methylation and regulation of the human beta-globin-like genes in mouse erythroleukemia cells containing human chromosome 11.
T J Ley, Y L Chiang, D Haidaris, N P Anagnou, V L Wilson, W F Anderson
Proceedings of the National Academy of Sciences of the United States of America   ·   01 Nov 1984   ·   pubmed:6208553
Human globin gene expression in hybrid 2S MEL X human fibroblast cells.
Human globin gene expression in hybrid 2S MEL X human fibroblast cells.
Y L Chiang, T J Ley, L Sanders-Haigh, W F Anderson
Somatic cell and molecular genetics   ·   01 Jul 1984   ·   pubmed:6589792
Beta O-39 thalassemia gene: a premature termination codon causes beta-mRNA deficiency without affecting cytoplasmic beta-mRNA stability.
Beta O-39 thalassemia gene: a premature termination codon causes beta-mRNA deficiency without affecting cytoplasmic beta-mRNA stability.
R K Humphries, T J Ley, N P Anagnou, A W Baur, A W Nienhuis
Blood   ·   01 Jul 1984   ·   pubmed:6733274
Advances in thalassemia research.
Advances in thalassemia research.
A W Nienhuis, N P Anagnou, T J Ley
Blood   ·   01 Apr 1984   ·   pubmed:6200160

1983

Acquired alpha-thalassemia in preleukemia is due to decreased expression of all four alpha-globin genes.
Acquired alpha-thalassemia in preleukemia is due to decreased expression of all four alpha-globin genes.
N P Anagnou, T J Ley, B Chesbro, G Wright, C Kitchens, S Liebhaber, A W Nienhuis, A B Deisseroth
Proceedings of the National Academy of Sciences of the United States of America   ·   01 Oct 1983   ·   pubmed:6136971
Inducible transcription of five globin genes in K562 human leukemia cells.
Inducible transcription of five globin genes in K562 human leukemia cells.
A Dean, T J Ley, R K Humphries, M Fordis, A N Schechter
Proceedings of the National Academy of Sciences of the United States of America   ·   01 Sep 1983   ·   pubmed:6310580
5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia.
5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia.
T J Ley, J DeSimone, C T Noguchi, P H Turner, A N Schechter, P Heller, A W Nienhuis
Blood   ·   01 Aug 1983   ·   pubmed:6191799
Chelation therapy for transfusion-dependent adults.
Chelation therapy for transfusion-dependent adults.
T J Ley, A W Nienhuis
The New England journal of medicine   ·   09 Jun 1983   ·   pubmed:6843638
A weak upstream promoter gives rise to long human beta-globin RNA molecules.
A weak upstream promoter gives rise to long human beta-globin RNA molecules.
T J Ley, A W Nienhuis
Biochemical and biophysical research communications   ·   16 May 1983   ·   pubmed:6303333
Spontaneous subarachnoid hemorrhage simulating acute transmural myocardial infarction.
Spontaneous subarachnoid hemorrhage simulating acute transmural myocardial infarction.
P Gascón, T J Ley, R J Toltzis, R O Bonow
American heart journal   ·   01 Mar 1983   ·   pubmed:6829411
5-azacytidine for beta thalassaemia?
5-azacytidine for beta thalassaemia?
T J Ley, N P Anagnou, N S Young, A W Nienhuis, J DeSimone, P Heller
Lancet (London, England)   ·   26 Feb 1983   ·   pubmed:6186873
DNA methylation and globin gene expression in patients treated with 5-azacytidine.
DNA methylation and globin gene expression in patients treated with 5-azacytidine.
T J Ley, N P Anagnou, C T Noguchi, A N Schechter, J DeSimone, P Heller, A W Nienhuis
Progress in clinical and biological research   ·   01 Jan 1983   ·   pubmed:6198660
Globin gene expression in somatic cell hybrids.
Globin gene expression in somatic cell hybrids.
W F Anderson, Y L Chiang, L Sanders-Haigh, T J Ley
Progress in clinical and biological research   ·   01 Jan 1983   ·   pubmed:6320217
Abundance and structure of globin mRNA in K562 human leukemia cells.
Abundance and structure of globin mRNA in K562 human leukemia cells.
A Dean, T J Ley, R K Humphries, C M Fordis, A N Schechter
Progress in clinical and biological research   ·   01 Jan 1983   ·   pubmed:6686681

1982

5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia.
5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia.
T J Ley, J DeSimone, N P Anagnou, G H Keller, R K Humphries, P H Turner, N S Young, P Keller, A W Nienhuis
The New England journal of medicine   ·   09 Dec 1982   ·   pubmed:6183586
RNA processing errors in patients with beta-thalassemia.
RNA processing errors in patients with beta-thalassemia.
T J Ley, N P Anagnou, G Pepe, A W Nienhuis
Proceedings of the National Academy of Sciences of the United States of America   ·   01 Aug 1982   ·   pubmed:6956887
Transfusion haemosiderosis and chelation therapy.
Transfusion haemosiderosis and chelation therapy.
T J Ley, P Griffith, A W Nienhuis
Clinics in haematology   ·   01 Jun 1982   ·   pubmed:7042160

fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection.
fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection.
M S Cheah, T J Ley, S R Tronick, K C Robbins
Nature   ·   [no date info]   ·   pubmed:3003578