All Publications
2023
Proteogenomic analysis reveals cytoplasmic sequestration of RUNX1 by the acute myeloid leukemia-initiating CBFB::MYH11 oncofusion protein.
The Journal of clinical investigation
·
07 Dec 2023
·
pubmed:38061017
Genomic landscape of TP53-mutated myeloid malignancies.
Blood advances
·
22 Aug 2023
·
pubmed:37339484
Melanoma in a patient with DNMT3A overgrowth syndrome.
Cold Spring Harbor molecular case studies
·
09 May 2023
·
pubmed:37160317
Persistent Molecular Disease in Adult Patients With AML Evaluated With Whole-Exome and Targeted Error-Corrected DNA Sequencing.
JCO precision oncology
·
01 Apr 2023
·
pubmed:37079859
Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions.
Blood
·
16 Feb 2023
·
pubmed:36179268
Genomic landscape of
medRxiv : the preprint server for health sciences
·
11 Jan 2023
·
pubmed:36711871
2022
IL-1β expression in bone marrow dendritic cells is induced by TLR2 agonists and regulates HSC function.
Blood
·
06 Oct 2022
·
pubmed:35675516
Proteomic and phosphoproteomic landscapes of acute myeloid leukemia.
Blood
·
29 Sep 2022
·
pubmed:35895896
Author Correction: A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing.
Nature communications
·
21 Jul 2022
·
pubmed:35864110
Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression.
Blood cancer discovery
·
06 Jul 2022
·
pubmed:35709710
Decitabine salvage for
Haematologica
·
01 Jul 2022
·
pubmed:35236053
Physician-scientists in the United States at 2020: Trends and concerns.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
·
01 May 2022
·
pubmed:35349197
Recurrent transcriptional responses in AML and MDS patients treated with decitabine.
Experimental hematology
·
13 Apr 2022
·
pubmed:35429619
Somatic
iScience
·
03 Mar 2022
·
pubmed:35313694
Bam-readcount - rapid generation of basepair-resolution sequence metrics
Journal of Open Source Software
·
29 Jan 2022
·
10.21105/joss.03722
DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults.
Blood
·
20 Jan 2022
·
pubmed:34788385
Failure to Detect Mutations in U2AF1 due to Changes in the GRCh38 Reference Sequence.
The Journal of molecular diagnostics : JMD
·
15 Jan 2022
·
pubmed:35041928
Tumor suppressor function of
Haematologica
·
01 Jan 2022
·
pubmed:34670359
2021
Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes.
Proceedings of the National Academy of Sciences of the United States of America
·
07 Dec 2021
·
pubmed:34845035
Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells.
Leukemia
·
06 Dec 2021
·
pubmed:34873300
Tumor suppressor function of Gata2 in acute promyelocytic leukemia.
Blood
·
30 Sep 2021
·
pubmed:34125173
Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia.
Blood cancer discovery
·
24 Aug 2021
·
pubmed:35019859
Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome.
Nature communications
·
27 Jul 2021
·
pubmed:34315901
Bam-readcount - rapid generation of basepair-resolution sequence metrics.
ArXiv
·
27 Jul 2021
·
pubmed:34341766
Co-evolution of tumor and immune cells during progression of multiple myeloma.
Nature communications
·
07 May 2021
·
pubmed:33963182
Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.
Proceedings of the National Academy of Sciences of the United States of America
·
20 Apr 2021
·
pubmed:33846253
Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers.
The New England journal of medicine
·
11 Mar 2021
·
pubmed:33704937
Impact of a 40-Gene Targeted Panel Test on Physician Decision Making for Patients With Acute Myeloid Leukemia.
JCO precision oncology
·
14 Jan 2021
·
pubmed:34036230
Enhanced Efficacy and Increased Long-Term Toxicity of CNS-Directed, AAV-Based Combination Therapy for Krabbe Disease.
Molecular therapy : the journal of the American Society of Gene Therapy
·
01 Jan 2021
·
pubmed:33388420
2020
The clonal evolution of metastatic colorectal cancer.
Science advances
·
10 Jun 2020
·
pubmed:32577507
Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression.
Nature communications
·
01 May 2020
·
pubmed:32358485
Remethylation of
Proceedings of the National Academy of Sciences of the United States of America
·
29 Jan 2020
·
pubmed:31996479
2019
A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing.
Nature communications
·
14 Aug 2019
·
pubmed:31413257
Immune Escape of AML Cells after Transplantation. Reply.
The New England journal of medicine
·
28 Mar 2019
·
pubmed:30917273
2018
Immune Escape of Relapsed AML Cells after Allogeneic Transplantation.
The New England journal of medicine
·
31 Oct 2018
·
pubmed:30380364
Mutation Clearance after Transplantation for Myelodysplastic Syndrome.
The New England journal of medicine
·
13 Sep 2018
·
pubmed:30207916
[no title info]
Cancer research
·
03 May 2018
·
pubmed:29724719
Sequencing of Tumor DNA to Guide Cancer Risk Assessment and Therapy.
JAMA
·
10 Apr 2018
·
pubmed:29634818
DNMT3A
Blood cancer journal
·
04 Apr 2018
·
pubmed:29618788
Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant.
JCI insight
·
08 Mar 2018
·
pubmed:29515031
Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential.
Nature communications
·
31 Jan 2018
·
pubmed:29386642
Expression profiling of snoRNAs in normal hematopoiesis and AML.
Blood advances
·
23 Jan 2018
·
pubmed:29365324
2017
Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies.
The Journal of clinical investigation
·
05 Sep 2017
·
pubmed:28872462
Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes.
Experimental hematology
·
28 Jul 2017
·
pubmed:28760689
Decitabine in TP53-Mutated AML.
The New England journal of medicine
·
23 Feb 2017
·
pubmed:28225682
CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
Cell
·
16 Feb 2017
·
pubmed:28215704
Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy.
Blood
·
12 Jan 2017
·
pubmed:28082444
2016
TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.
The New England journal of medicine
·
24 Nov 2016
·
pubmed:27959731
Visualizing tumor evolution with the fishplot package for R.
BMC genomics
·
07 Nov 2016
·
pubmed:27821060
Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy.
Leukemia
·
14 Oct 2016
·
pubmed:27740633
Targeted sequencing informs the evaluation of normal karyotype cytopenic patients for low-grade myelodysplastic syndrome.
Leukemia
·
30 Aug 2016
·
pubmed:27573557
Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.
Experimental hematology
·
13 May 2016
·
pubmed:27181063
2015
Patterns and functional implications of rare germline variants across 12 cancer types.
Nature communications
·
22 Dec 2015
·
pubmed:26689913
Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.
Blood
·
02 Dec 2015
·
pubmed:26631115
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
The Journal of clinical investigation
·
23 Nov 2015
·
pubmed:26595813
Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.
Blood
·
22 Oct 2015
·
pubmed:26492932
Optimizing cancer genome sequencing and analysis.
Cell systems
·
23 Sep 2015
·
pubmed:26645048
Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.
JAMA
·
25 Aug 2015
·
pubmed:26305651
Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma.
Clinical cancer research : an official journal of the American Association for Cancer Research
·
29 Apr 2015
·
pubmed:25925892
Genetic heterogeneity of induced pluripotent stem cells: results from 24 clones derived from a single C57BL/6 mouse.
PloS one
·
23 Mar 2015
·
pubmed:25799070
Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing.
Leukemia
·
03 Feb 2015
·
pubmed:25644247
Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells.
Leukemia
·
20 Jan 2015
·
pubmed:25600023
2014
Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.
Nature
·
08 Dec 2014
·
pubmed:25487151
Clonal architectures and driver mutations in metastatic melanomas.
PloS one
·
13 Nov 2014
·
pubmed:25393105
Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.
Blood
·
27 Oct 2014
·
pubmed:25349173
Age-related mutations associated with clonal hematopoietic expansion and malignancies.
Nature medicine
·
19 Oct 2014
·
pubmed:25326804
U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing.
Leukemia
·
14 Oct 2014
·
pubmed:25311244
Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia.
Leukemia
·
25 Sep 2014
·
pubmed:25252869
SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution.
PLoS computational biology
·
07 Aug 2014
·
pubmed:25102416
Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro.
Leukemia
·
31 Jul 2014
·
pubmed:25092143
Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing.
PLoS genetics
·
10 Jul 2014
·
pubmed:25010716
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers.
Cancer cell
·
20 Mar 2014
·
pubmed:24656771
Functional heterogeneity of genetically defined subclones in acute myeloid leukemia.
Cancer cell
·
06 Mar 2014
·
pubmed:24613412
2013
Mutational landscape and significance across 12 major cancer types.
Nature
·
17 Oct 2013
·
pubmed:24132290
DGIdb: mining the druggable genome.
Nature methods
·
13 Oct 2013
·
pubmed:24122041
Genomic landscapes and clonality of de novo AML.
The New England journal of medicine
·
10 Oct 2013
·
pubmed:24106950
Acquired copy number alterations of miRNA genes in acute myeloid leukemia are uncommon.
Blood
·
05 Sep 2013
·
pubmed:24009227
BreakTrans: uncovering the genomic architecture of gene fusions.
Genome biology
·
23 Aug 2013
·
pubmed:23972288
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.
The New England journal of medicine
·
01 May 2013
·
pubmed:23634996
Notch signaling in acute promyelocytic leukemia.
Leukemia
·
04 Mar 2013
·
pubmed:23455394
Clonal diversity of recurrently mutated genes in myelodysplastic syndromes.
Leukemia
·
27 Feb 2013
·
pubmed:23443460
Genomic impact of transient low-dose decitabine treatment on primary AML cells.
Blood
·
07 Jan 2013
·
pubmed:23297133
2012
An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.
Cancer cell
·
13 Nov 2012
·
pubmed:23153540
Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice.
PloS one
·
08 Oct 2012
·
pubmed:23056333
The origin and evolution of mutations in acute myeloid leukemia.
Cell
·
20 Jul 2012
·
pubmed:22817890
Whole-genome analysis informs breast cancer response to aromatase inhibition.
Nature
·
10 Jun 2012
·
pubmed:22722193
The Pediatric Cancer Genome Project.
Nature genetics
·
29 May 2012
·
pubmed:22641210
BreakFusion: targeted assembly-based identification of gene fusions in whole transcriptome paired-end sequencing data.
Bioinformatics (Oxford, England)
·
04 May 2012
·
pubmed:22563071
Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells.
Cell stem cell
·
26 Apr 2012
·
pubmed:22542160
Clonal architecture of secondary acute myeloid leukemia.
The New England journal of medicine
·
14 Mar 2012
·
pubmed:22417201
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing.
Nature
·
11 Jan 2012
·
pubmed:22237025
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.
Nature
·
11 Jan 2012
·
pubmed:22237106
2011
Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.
Nature genetics
·
11 Dec 2011
·
pubmed:22158538
SomaticSniper: identification of somatic point mutations in whole genome sequencing data.
Bioinformatics (Oxford, England)
·
06 Dec 2011
·
pubmed:22155872
Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML.
JAMA
·
20 Apr 2011
·
pubmed:21505135
Use of whole-genome sequencing to diagnose a cryptic fusion oncogene.
JAMA
·
20 Apr 2011
·
pubmed:21505136
PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice.
The Journal of clinical investigation
·
01 Apr 2011
·
pubmed:21364283
Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression.
The Journal of clinical investigation
·
23 Mar 2011
·
pubmed:21436584
Recurrent DNMT3A mutations in patients with myelodysplastic syndromes.
Leukemia
·
18 Mar 2011
·
pubmed:21415852
2010
Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.
Blood
·
29 Dec 2010
·
pubmed:21190992
DNMT3A mutations in acute myeloid leukemia.
The New England journal of medicine
·
10 Nov 2010
·
pubmed:21067377
Next-generation sequencing identifies the natural killer cell microRNA transcriptome.
Genome research
·
08 Oct 2010
·
pubmed:20935160
Complete characterization of the microRNAome in a patient with acute myeloid leukemia.
Blood
·
28 Sep 2010
·
pubmed:20876853
A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia.
Blood
·
20 Jul 2010
·
pubmed:20647568
Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.
The Journal of clinical investigation
·
17 May 2010
·
pubmed:20484815
International network of cancer genome projects.
Nature
·
15 Apr 2010
·
pubmed:20393554
Genome remodelling in a basal-like breast cancer metastasis and xenograft.
Nature
·
15 Apr 2010
·
pubmed:20393555
POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature.
Leukemia
·
08 Apr 2010
·
pubmed:20376082
Latent herpesvirus infection arms NK cells.
Blood
·
04 Feb 2010
·
pubmed:20139098
2009
Granzyme B is not required for regulatory T cell-mediated suppression of graft-versus-host disease.
Blood
·
13 Nov 2009
·
pubmed:19965675
Next-generation sequencing of cancer genomes: back to the future.
Personalized medicine
·
01 Nov 2009
·
pubmed:20161678
Interleukin 12 stimulates IFN-gamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance.
Cancer research
·
20 Oct 2009
·
pubmed:19843867
BreakDancer: an algorithm for high-resolution mapping of genomic structural variation.
Nature methods
·
09 Aug 2009
·
pubmed:19668202
Recurring mutations found by sequencing an acute myeloid leukemia genome.
The New England journal of medicine
·
05 Aug 2009
·
pubmed:19657110
Acquired copy number alterations in adult acute myeloid leukemia genomes.
Proceedings of the National Academy of Sciences of the United States of America
·
27 Jul 2009
·
pubmed:19651600
High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples.
The Journal of clinical investigation
·
18 May 2009
·
pubmed:19451695
Differential expression of granzyme B and C in murine cytotoxic lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
·
15 May 2009
·
pubmed:19414782
2008
Sociology. The gender gap in NIH grant applications.
Science (New York, N.Y.)
·
05 Dec 2008
·
pubmed:19056961
Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100.
Blood
·
02 Dec 2008
·
pubmed:19050309
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.
Nature
·
06 Nov 2008
·
pubmed:18987736
Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice.
Blood
·
13 Jun 2008
·
pubmed:18552208
wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data.
Nucleic acids research
·
11 Mar 2008
·
pubmed:18334530
Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia.
Genome biology
·
21 Feb 2008
·
pubmed:18291030
Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.
Blood
·
12 Feb 2008
·
pubmed:18270328
2007
Identification of somatic JAK1 mutations in patients with acute myeloid leukemia.
Blood
·
26 Dec 2007
·
pubmed:18160671
Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance.
Immunity
·
04 Oct 2007
·
pubmed:17919943
Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs.
Immunity
·
31 May 2007
·
pubmed:17540585
Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia.
Blood
·
09 May 2007
·
pubmed:17494858
2006
A high-resolution map of segmental DNA copy number variation in the mouse genome.
PLoS genetics
·
22 Nov 2006
·
pubmed:17206864
Commonly dysregulated genes in murine APL cells.
Blood
·
28 Sep 2006
·
pubmed:17008535
Hop cleavage and function in granzyme B-induced apoptosis.
The Journal of biological chemistry
·
27 Sep 2006
·
pubmed:17005566
Cold shock domain family members YB-1 and MSY4 share essential functions during murine embryogenesis.
Molecular and cellular biology
·
05 Sep 2006
·
pubmed:16954378
Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease.
Blood
·
04 May 2006
·
pubmed:16675706
2005
The physician-scientist career pipeline in 2005: build it, and they will come.
JAMA
·
21 Sep 2005
·
pubmed:16174692
Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.
Proceedings of the National Academy of Sciences of the United States of America
·
19 Aug 2005
·
pubmed:16113082
Murine acute promyelocytic leukemia cells can be recognized and cleared in vivo by adaptive immune mechanisms.
Haematologica
·
01 Aug 2005
·
pubmed:16079103
YB-1 is important for late-stage embryonic development, optimal cellular stress responses, and the prevention of premature senescence.
Molecular and cellular biology
·
01 Jun 2005
·
pubmed:15899865
Retrospective: Stanley Joel Korsmeyer (1950-2005).
Science (New York, N.Y.)
·
06 May 2005
·
pubmed:15879200
Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions.
Journal of immunology (Baltimore, Md. : 1950)
·
15 Feb 2005
·
pubmed:15699143
Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells.
Molecular and cellular biology
·
01 Jan 2005
·
pubmed:15601827
Use of protease proteomics to discover granzyme B substrates.
Immunologic research
·
01 Jan 2005
·
pubmed:16106065
2004
Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans.
Journal of immunology (Baltimore, Md. : 1950)
·
15 Dec 2004
·
pubmed:15585850
Expression profiling of murine acute promyelocytic leukemia cells reveals multiple model-dependent progression signatures.
Molecular and cellular biology
·
01 Dec 2004
·
pubmed:15572690
Granzymes and caspase 3 play important roles in control of gammaherpesvirus latency.
Journal of virology
·
01 Nov 2004
·
pubmed:15507639
Human T regulatory cells can use the perforin pathway to cause autologous target cell death.
Immunity
·
01 Oct 2004
·
pubmed:15485635
Granzymes A and B are not expressed in human neutrophils.
Blood
·
01 Aug 2004
·
pubmed:15265800
A proteomic approach for the discovery of protease substrates.
Proceedings of the National Academy of Sciences of the United States of America
·
27 Jul 2004
·
pubmed:15280543
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells.
Blood
·
06 Jul 2004
·
pubmed:15238416
2003
1998 ASCI Presidential Address.
The Journal of clinical investigation
·
01 Dec 2003
·
pubmed:14702962
A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes.
Proceedings of the National Academy of Sciences of the United States of America
·
12 Nov 2003
·
pubmed:14614138
Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice.
Cell
·
31 Oct 2003
·
pubmed:14636558
The orphan granzymes of humans and mice.
Current opinion in immunology
·
01 Oct 2003
·
pubmed:14499263
High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression.
Blood
·
15 May 2003
·
pubmed:12750176
Long targeting arms do not increase the efficiency of homologous recombination in the beta-globin locus of murine embryonic stem cells.
Blood
·
01 May 2003
·
pubmed:12730107
Mutational profiling in the human genome.
Cold Spring Harbor symposia on quantitative biology
·
01 Jan 2003
·
pubmed:15338599
2002
Cell death induced by granzyme C.
Blood
·
19 Dec 2002
·
pubmed:12515723
Adaptive immunity cooperates with liposomal all-trans-retinoic acid (ATRA) to facilitate long-term molecular remissions in mice with acute promyelocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America
·
20 Jun 2002
·
pubmed:12077315
PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model.
Proceedings of the National Academy of Sciences of the United States of America
·
11 Jun 2002
·
pubmed:12060771
Removing career obstacles for young physician-scientists -- loan-repayment programs.
The New England journal of medicine
·
31 Jan 2002
·
pubmed:11821517
2001
Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.
Proceedings of the National Academy of Sciences of the United States of America
·
18 Dec 2001
·
pubmed:11752447
Lymphocyte-mediated cytotoxicity.
Annual review of immunology
·
04 Oct 2001
·
pubmed:11861606
Sudden death among patients with acute promyelocytic leukemia treated with arsenic trioxide.
Blood
·
15 Jul 2001
·
pubmed:11435292
Mouse models of acute promyelocytic leukemia.
Current opinion in hematology
·
01 Jul 2001
·
pubmed:11561157
Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice.
The Journal of biological chemistry
·
23 Feb 2001
·
pubmed:11279033
2000
Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America
·
21 Nov 2000
·
pubmed:11087871
Independent formation of DnaseI hypersensitive sites in the murine beta-globin locus control region.
Blood
·
01 Jun 2000
·
pubmed:10828050
DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis.
Immunity
·
01 Jun 2000
·
pubmed:10894162
The physician-scientist: career issues and challenges at the year 2000.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
·
01 Feb 2000
·
pubmed:10657979
Deletions within the mouse beta-globin locus control region preferentially reduce beta(min) globin gene expression.
Genomics
·
01 Feb 2000
·
pubmed:10704289
1999
A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America
·
21 Dec 1999
·
pubmed:10611345
Normal neutrophil function in cathepsin G-deficient mice.
Blood
·
15 Dec 1999
·
pubmed:10590073
Transgenic analysis of a 100-kb human beta-globin cluster-containing DNA fragment propagated as a bacterial artificial chromosome.
Blood
·
01 Nov 1999
·
pubmed:10556205
Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo.
Proceedings of the National Academy of Sciences of the United States of America
·
20 Jul 1999
·
pubmed:10411926
Granzyme A initiates an alternative pathway for granule-mediated apoptosis.
Immunity
·
01 May 1999
·
pubmed:10367905
Seed versus soil: the importance of the target cell for transgenic models of human leukemias.
Blood
·
01 Apr 1999
·
pubmed:10090920
1998
How do cytotoxic lymphocytes kill their targets?
Current opinion in immunology
·
01 Oct 1998
·
pubmed:9794837
Augmented inflammatory responses and altered wound healing in cathepsin G-deficient mice.
Archives of surgery (Chicago, Ill. : 1960)
·
01 Sep 1998
·
pubmed:9749856
Reduced beta-globin gene expression in adult mice containing deletions of locus control region 5' HS-2 or 5' HS-3.
Annals of the New York Academy of Sciences
·
30 Jun 1998
·
pubmed:9668526
Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene.
Nucleic acids research
·
15 Jun 1998
·
pubmed:9611227
Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis.
Nature medicine
·
01 May 1998
·
pubmed:9585238
Production of fully active recombinant murine granzyme B in yeast.
The Journal of biological chemistry
·
16 Jan 1998
·
pubmed:9430705
1997
Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation.
The Journal of clinical investigation
·
15 Aug 1997
·
pubmed:9259590
Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes.
The Journal of biological chemistry
·
08 Aug 1997
·
pubmed:9242702
Mechanisms responsible for granzyme B-independent cytotoxicity.
Blood
·
01 Jun 1997
·
pubmed:9166849
Molecular cloning, chromosomal localization, and expression of murine dipeptidyl peptidase I.
The Journal of biological chemistry
·
18 Apr 1997
·
pubmed:9099719
The role of granzyme B cluster proteases in cell-mediated cytotoxicity.
Seminars in immunology
·
01 Apr 1997
·
pubmed:9194223
Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences.
Blood
·
15 Jan 1997
·
pubmed:9002938
1996
Long-range disruption of gene expression by a selectable marker cassette.
Proceedings of the National Academy of Sciences of the United States of America
·
12 Nov 1996
·
pubmed:8917549
Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation.
The Journal of biological chemistry
·
06 Sep 1996
·
pubmed:8702964
Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3.
Molecular and cellular biology
·
01 Jun 1996
·
pubmed:8649401
How do lymphocytes kill tumor cells?
Clinical cancer research : an official journal of the American Association for Cancer Research
·
01 May 1996
·
pubmed:9816231
Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice.
Proceedings of the National Academy of Sciences of the United States of America
·
30 Apr 1996
·
pubmed:8632994
The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection.
Blood
·
15 Feb 1996
·
pubmed:8608209
Regulation of azurophil granule-associated serine protease genes during myelopoiesis.
Current opinion in hematology
·
01 Jan 1996
·
pubmed:9372052
1995
An intramolecular triplex in the human gamma-globin 5'-flanking region is altered by point mutations associated with hereditary persistence of fetal hemoglobin.
The Journal of biological chemistry
·
13 Oct 1995
·
pubmed:7592674
Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.
Genes & development
·
15 Sep 1995
·
pubmed:7557375
Granzyme B plays a critical role in cytotoxic lymphocyte-induced apoptosis.
Immunological reviews
·
01 Aug 1995
·
pubmed:7493755
Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.
Proceedings of the National Academy of Sciences of the United States of America
·
06 Jun 1995
·
pubmed:7777569
Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.
Proceedings of the National Academy of Sciences of the United States of America
·
14 Feb 1995
·
pubmed:7862633
1994
Early myeloid cell-specific expression of the human cathepsin G gene in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America
·
13 Sep 1994
·
pubmed:8090757
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A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes.
The Journal of biological chemistry
·
13 May 1994
·
pubmed:8188694
Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.
Cell
·
25 Mar 1994
·
pubmed:8137431
1993
Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages.
The Journal of biological chemistry
·
15 Nov 1993
·
pubmed:8226919
Consensus AP-1 and CRE motifs upstream from the human cytotoxic serine protease B (CSP-B/CGL-1) gene synergize to activate transcription.
Blood
·
01 Nov 1993
·
pubmed:8219227
Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene.
Blood
·
15 Mar 1993
·
pubmed:8453108
The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression.
Genomics
·
01 Mar 1993
·
pubmed:8468056
1992
Structure and function of the murine beta-globin locus control region 5' HS-3.
Nucleic acids research
·
11 Nov 1992
·
pubmed:1454538
An intramolecular DNA triplex is disrupted by point mutations associated with hereditary persistence of fetal hemoglobin.
The Journal of biological chemistry
·
15 Sep 1992
·
pubmed:1382059
Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter.
Oncogene
·
01 May 1992
·
pubmed:1373875
Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase.
The Journal of biological chemistry
·
05 Mar 1992
·
pubmed:1537850
A-T-rich scaffold attachment regions flank the hematopoietic serine protease genes clustered on chromosome 14q11.2.
Blood
·
01 Feb 1992
·
pubmed:1732006
Neutral proteinase expression by human mononuclear phagocytes: a prominent role of cellular differentiation.
Matrix (Stuttgart, Germany). Supplement
·
01 Jan 1992
·
pubmed:1480061
1991
The 5'-flanking region of the human CGL-1/granzyme B gene targets expression of a reporter gene to activated T-lymphocytes in transgenic mice.
The Journal of biological chemistry
·
25 Dec 1991
·
pubmed:1761544
1,25-Dihydroxyvitamin D3 induces monocytic differentiation of the PLB-985 leukemic line and promotes c-fgr mRNA expression.
Journal of leukocyte biology
·
01 Nov 1991
·
pubmed:1660912
Functional properties of the beta-globin locus control region in K562 erythroleukemia cells.
Blood
·
15 May 1991
·
pubmed:1709381
Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2.
The Journal of biological chemistry
·
05 Apr 1991
·
pubmed:2007574
The pharmacology of hemoglobin switching: of mice and men.
Blood
·
15 Mar 1991
·
pubmed:1705828
A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes.
Molecular and cellular biology
·
01 Mar 1991
·
pubmed:1847500
1990
Transcriptional activation of the human cytotoxic serine protease gene CSP-B in T lymphocytes.
Molecular and cellular biology
·
01 Nov 1990
·
pubmed:2233710
Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions.
Proceedings of the National Academy of Sciences of the United States of America
·
01 Oct 1990
·
pubmed:2217202
Function of normal and mutated gamma-globin gene promoters in electroporated K562 erythroleukemia cells.
Blood
·
15 Feb 1990
·
pubmed:1689192
A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus.
Proceedings of the National Academy of Sciences of the United States of America
·
01 Feb 1990
·
pubmed:2300587
Developmental regulation of the human cathepsin G gene in myelomonocytic cells.
The Journal of biological chemistry
·
25 Jan 1990
·
pubmed:2295643
Function of transfected globin promoters and the globin locus activator in K562 erythroleukemia cells.
Annals of the New York Academy of Sciences
·
01 Jan 1990
·
pubmed:2291547
1989
Nucleotide sequence and regulation of a human 90-kDa heat shock protein gene.
The Journal of biological chemistry
·
05 Sep 1989
·
pubmed:2768249
Genomic organization and chromosomal localization of the human cathepsin G gene.
The Journal of biological chemistry
·
15 Aug 1989
·
pubmed:2569462
Analysis of epitope expression and the functional repertoire of recombinant complement receptor 2 (CR2/CD21) in mouse and human cells.
Journal of immunology (Baltimore, Md. : 1950)
·
01 Aug 1989
·
pubmed:2473114
Globin gene expression in erythroid human fetal liver cells.
The Journal of clinical investigation
·
01 Mar 1989
·
pubmed:2921315
Regulatory regions flanking the human fetal gamma-globin genes.
Annals of the New York Academy of Sciences
·
01 Jan 1989
·
pubmed:2476058
Tissue-specific expression and developmental regulation of the human fgr proto-oncogene.
Molecular and cellular biology
·
01 Jan 1989
·
pubmed:2538725
1988
High-resolution analysis of the human gamma-globin gene promoter in K562 erythroleukemia cell chromatin.
Blood
·
01 Aug 1988
·
pubmed:3165297
1987
An enhancer element lies 3' to the human A gamma globin gene.
The EMBO journal
·
01 Oct 1987
·
pubmed:3691478
A transient assay system to study gamma globin gene expression in K562 cells.
Progress in clinical and biological research
·
01 Jan 1987
·
pubmed:3432267
1986
Hydroxyurea induction of hemoglobin F production in sickle cell disease: relationship between cytotoxicity and F cell production.
Blood
·
01 Mar 1986
·
pubmed:2418898
Induction of fgr proto-oncogene mRNA in B lymphocytes as a consequence of Epstein-Barr virus infection.
Current topics in microbiology and immunology
·
01 Jan 1986
·
pubmed:3024916
1985
Pharmacological manipulation of fetal hemoglobin synthesis in patients with severe beta-thalassemia.
Annals of the New York Academy of Sciences
·
01 Jan 1985
·
pubmed:2409872
Disseminated infection caused by Cunninghamella bertholletiae in a patient with beta-thalassemia. Case report and review of the literature.
Annals of internal medicine
·
01 Jan 1985
·
pubmed:2578267
Induction of hemoglobin F synthesis in patients with beta thalassemia.
Annual review of medicine
·
01 Jan 1985
·
pubmed:2581500
1984
DNA methylation and regulation of the human beta-globin-like genes in mouse erythroleukemia cells containing human chromosome 11.
Proceedings of the National Academy of Sciences of the United States of America
·
01 Nov 1984
·
pubmed:6208553
Human globin gene expression in hybrid 2S MEL X human fibroblast cells.
Somatic cell and molecular genetics
·
01 Jul 1984
·
pubmed:6589792
Beta O-39 thalassemia gene: a premature termination codon causes beta-mRNA deficiency without affecting cytoplasmic beta-mRNA stability.
Blood
·
01 Jul 1984
·
pubmed:6733274
Advances in thalassemia research.
Blood
·
01 Apr 1984
·
pubmed:6200160
1983
Acquired alpha-thalassemia in preleukemia is due to decreased expression of all four alpha-globin genes.
Proceedings of the National Academy of Sciences of the United States of America
·
01 Oct 1983
·
pubmed:6136971
Inducible transcription of five globin genes in K562 human leukemia cells.
Proceedings of the National Academy of Sciences of the United States of America
·
01 Sep 1983
·
pubmed:6310580
5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia.
Blood
·
01 Aug 1983
·
pubmed:6191799
Chelation therapy for transfusion-dependent adults.
The New England journal of medicine
·
09 Jun 1983
·
pubmed:6843638
A weak upstream promoter gives rise to long human beta-globin RNA molecules.
Biochemical and biophysical research communications
·
16 May 1983
·
pubmed:6303333
Spontaneous subarachnoid hemorrhage simulating acute transmural myocardial infarction.
American heart journal
·
01 Mar 1983
·
pubmed:6829411
5-azacytidine for beta thalassaemia?
Lancet (London, England)
·
26 Feb 1983
·
pubmed:6186873
DNA methylation and globin gene expression in patients treated with 5-azacytidine.
Progress in clinical and biological research
·
01 Jan 1983
·
pubmed:6198660
Globin gene expression in somatic cell hybrids.
Progress in clinical and biological research
·
01 Jan 1983
·
pubmed:6320217
Abundance and structure of globin mRNA in K562 human leukemia cells.
Progress in clinical and biological research
·
01 Jan 1983
·
pubmed:6686681
1982
5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia.
The New England journal of medicine
·
09 Dec 1982
·
pubmed:6183586
RNA processing errors in patients with beta-thalassemia.
Proceedings of the National Academy of Sciences of the United States of America
·
01 Aug 1982
·
pubmed:6956887
Transfusion haemosiderosis and chelation therapy.
Clinics in haematology
·
01 Jun 1982
·
pubmed:7042160
fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection.
Nature
·
[no date info]
·
pubmed:3003578